Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-09-06
1997-11-25
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, C12Q 168
Patent
active
056911530
ABSTRACT:
The invention provides the chromosome location of an autosomal dominant gene associated with high bone mass. As a result of this localization, the presence of a polymorphism linked to the autosomal dominant gene in a subject can be detected by analyzing human chromosome 11 of the subject for the presence of the polymorphism located about 30 cM around D11S987 and linked to the autosomal dominant gene. The analysis of chromosome 11 can be accomplished by amplifying the polymorphism, separating the amplified polymorphism to generate a polymorphism pattern, and correlating the presence or absence of the polymorphism with the respective presence or absence of the autosomal dominant gene associated with high bone mass.
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Gong Guodong
Johnson Mark L.
Kimmel Donald B.
Recker Robert R.
Recker Susan M.
Creighton University
Ketter James
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