Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-09-26
1996-08-27
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 221, 536 231, 536 243, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2104
Patent
active
055500242
ABSTRACT:
Disclosed herein are genetic markers for pig litter size, methods for identifying such markers, and methods of screening pigs to determine those more likely to produce larger litters and preferably selecting those pigs for future breeding purposes based on the ESR polymorphisms. The markers are based upon the presence or absence of certain polymorphisms in the pig estrogen receptor gene. Preferably, the polymorphism is a restriction fragment length polymorphism (RFLP).
REFERENCES:
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patent: 5374526 (1994-12-01), Rothschild et al.
Koike et al., (1987), "The steroid binding domain of porcine estrogen receptor", Biochemistry 26: 2563-2658.
Koike et al., (1987), "Molecular cloning and characterization of rat estrogen receptor cDNA", Nucleic Acids Res. 15(6): 2499-2513.
Stratagene catalog (1988) p. 39.
Rothschild et al., (1992), "Estrogen receptor gene restriction fragment length polymorphism in U.S. breeds of swine", J. Animal Sci. 70 (suppl 1) p. 41.
Walter et al., (1985), "Cloning of the human estrogen receptor cDNA", Proc. Natl. Acad. Sci. 82: 7889-7893.
Niemann et al., (1986), "Evidence for estrogen-dependent blastocyst formation in pig", Biology Reproduction 35: 10-16.
Rothschild et al., (1991), "Pvull polymorphisms at the porcine oestrogen receptor Iocus (ESR)", Animal Genet. 22: 448.
Rothschild et al., (1991), "Genetic variability of the swine estrogen receptor and heat shock genes and there relationship to reproduction and health", J. Animal Sci. 69 (suppl 1): 200.
(1994), "Major gene controls litter size", National Hog Farmer 39 (14): 17-18.
Jacobson Carol D.
Mileham Alan J.
Plastow Graham S.
Rothschild Max F.
Tuggle Christopher K.
Biotechnology Research & Development Corporation
Fredman Jeffrey
Iowa State University & Research Foundation, Inc.
Jones W. Gary
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