Genetic markers for improved disease resistance in animals...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C435S091200, C536S023500, C536S024310

Reexamination Certificate

active

07070929

ABSTRACT:
A method for determining improved disease resistance in animals is disclosed. The method assays for a novel genetic alleles of the BPI gene of the animal. The alleles are correlated with superior disease resistance. Novel nucleotide sequences, assays and primers are disclosed for the methods of the invention.

REFERENCES:
patent: 02741782 (2005-02-01), None
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Hubacek, Jaroslav A., et al. “Short Report on DNA Marker at Candidate Locus” Genet 1997; 52:249, XP-002955925.
Jagiello, P., et al., Association Study of Wegener Granulomatosis and the Functionally Relevant A645G Polymorphism in the Bactericidal/Permeability Increasing Protein (BPI) Gene; 2005 Blackwell Publishing, International Journal of Immunogenetics 32, 3-6; XP-002318095.
Leong, Steven R., et al. Nucleotide Sequence of the Bovine Bactericidal Permeability Increasing Protein (BPI); 3052 Nucleic Acids Research, vol. 18, No. 10, 1990 Oxford University Press.
Vandermeer, Thomas J. et al., “Bactericidal/permeability-increasing Protein Amellorates Acute Lung Injury in Porcine Endotoxemia” 1994 American Physiological Society. pp. 2006-2014.

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