Genetic markers for breast, ovarian, and prostatic cancer

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 912, 536 231, 536 243, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

056228295

ABSTRACT:
Specific BRCA1 mutations, PCR primers and hybridization probes are used in nucleic acid-based methods for diagnostic of inheritable breast cancer susceptibility. Additionally, binding agents, such as antibodies, specific for peptides encoded by the subject BRCA1 mutants are used to identify expression products of diagnostic mutations/rare alleles in patient derived fluid or tissue samples. Compositions with high binding affinity for transcription or translation products of the disclosed BRCA1 mutations and alleles are used in therapeutic intervention. Such products include anti-sense nucleic acids, peptides encoded by the subject nucleic acids, and binding agents such as antibodies, specific for such peptides.

REFERENCES:
Hovig et al., "Searching Candidate Genes for Mutations", In Current Protocols in Human Genetics, published by Current Protocols, pp. 7.3.1-7.4.6 1994.
Gayther et al, Rapid Detection of Regionally Clustered Germ-Line BRCA 1 "Mutations by Multiplex Heteroduplex Analysis", Am. J. of Hum. Genet 58:451-456 1995.
Manak et al. in DNA Probes,, McMillan Publishers 1993, pp. 422-427 1993.
Zhang et al. Nar 19: 3929-3933, 1991.
Merajver et al. Nature Genetics 9: 439-443 1995.
Hosking et al. Nature Genetics 9: 343-344, 1995.
Futreal et al. Science 266: 120-122 1994.
Boyd, Nature Gentics 9: 335-336 1995.
Goldgar et al. J. of the Nat. Cancer Inst 86: 200-209 1994.
Simard et al. Nature Genetics 8: 392-398 1994.
Castilla et al. Nature Genetics 8:387-391 1994.
Shattuck-Eidens JAMA 273: 535-541 1995.
Miki et al. Science 266: 6671 1994.
Neuhausen et al. Human Molecular Genetics 3: 1919-1926, 1994.
Barany, PNAS 88: 189-193, 1991.
Roberts, Science 259: 622-625 1993.
Goldberg et al. Clin Chem 39: 2360-2374 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Genetic markers for breast, ovarian, and prostatic cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genetic markers for breast, ovarian, and prostatic cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetic markers for breast, ovarian, and prostatic cancer will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-340780

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.