Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-05-16
1997-03-25
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 436 94, 536 235, 536 2433, 536 253, 935 76, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C12N 1500
Patent
active
056143648
ABSTRACT:
Genetic markers in the bovine PIT-1 gene are disclosed which are associated with increased milk production and increased protein and fat content in cattle. Further, novel sequence data from intron regions of the gene are disclosed which may be used in a PCR test to screen for the presence of the marker.
REFERENCES:
Ingraham, 1988, "A Tissue-Specific Transcription Factor Containing a Homeodomain Specifies a Pituitary Phenotype", Cell, vol. 55:519-529.
Wiggans, 1989, "USDA-DHIA Animal Model Genetic Evaluations", National Cooperative Dairy Herd Improvement Program, Fact Sheet H-2, 1-8.
Wiggans, 1988, "Implementation of an Animal Model for Genetic Evaluation of Dairy Cattle in the United States", pp. 54-69.
Voss, 1992, "Anterior Pituitary Development: Short Tales From Dwarf Mice", Cell, vol. 70:527-530.
Steinfelder, 1991, "Thyrotropin-Releasing Hormone Regulation of Human TSHB Expression: Role of a Pituitary-Specific Transcription Factor (Pit-1/GHF-1) and Potential Interaction With a Thyroid Hormone-Inhibitory Element", Proc. Natl. Acad. Sci. USA, vol. 88:3130-3134.
Bodner, 1988, "The Pituitary-Specific Transcription Factor GHF-1 Is a Homeobox-Containing Protein", Cell, vol. 55:505-518.
Welper, 1992, "Genetic Parameters for Yield Traits of Holsteins, Including Lactose and Somatic Cell Score", J. Dairy Sci. 57:1342-1348.
Pfaffle, 1992, "Mutation of the POU-Specific Domain of Pit-1 and Hypopituitarism Without Pituitary Hypoplasia", Science 257:1118-1121.
Radovick, 1992, "A Mutation in the POU-Homeodomain of Pit-1 Responsible for Combined Pituitary Hormone Defiency", Science 257:1115-1118.
Ohta, 1992, "Mutations in the PIT-1 Gene in Children With Combined Pituitary Hormone Deficiency", Biochemical and Biophysical Research Communications, pp. 851-855.
Li, 1990, "Dwarf Locus Mutants Lacking Three Pituitary Cell Types Result From Mutations in the POU-Domain Gene PIT-1", Nature 347:528-533.
Tsukahara et alii, Environ Med (Nagoya), 36 (0), 1992, pp. 55-58; Abstract Only New England BioLabs.RTM. 1988-1989 Catalog, p. 62.
Freeman Albert E.
Tuggle Christopher K.
Iowa State University & Research Foundation, Inc.
Sisson Bradley L.
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