Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-08-13
1999-09-21
Stanton, Brian R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
A01N 4304
Patent
active
059554410
ABSTRACT:
A method and means for protecting cells and transplanted organs from the effects of activated complement proteins generated in blood serum or plasma by introducing the gene for CD59 into the cells to be protected is described. In an example of the method, protection against the pore-forming activity of the human C5b-9 proteins was conferred on CHO cells by transfection with cDNA encoding the human complement regulatory protein CD59.
REFERENCES:
Walsh et al. Transfection of human CD59 complementary DNA into rat cells confers resistance to human complement. Eur. J. of Immun., vol. 21, No. 3, pp. 847-850, Mar. 1991.
Weatherall, D J. Scope and limitations of gene therapy. British Medical Bulletin, vol. 51, No. 1, pp. 1-11, 1995.
NIH panel. Report and recommendations of the Panel to Assess the NIH investment in research on gene therapy, Dec. 07, 1995.
Bothwell Alfred L.M.
Sims Peter J.
Clark Deborah J. R.
Oklahoma Medical Research Foundation
Stanton Brian R.
Yale University
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