Genetic induction of receptors for targeted radiotherapy

Details Genetic induction of receptors for targeted radiotherapy Genetic induction of receptors for targeted radiotherapy

1997-10-09

1999-11-09

Campbell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 141, 424 145, 424 149, 424 169, A61K 4800

Patent

active

059815043

ABSTRACT:
The present invention provides a method to achieve radioisotopic localization at tumor sites, i.e., a method of enhancing radiolabeled ligand localization to a tumor in an individual in need of such treatment, comprising the steps of: transducing said tumor with a gene encoding a membrane expressed protein unique to said tumor; and administering to said individual a radiolabeled ligand which specifically binds to said protein. The use of gene therapy technology to induce expression of high affinity membrane molecules/receptors can enhance the specificity of radioisotope localization while the use of radioactive isotopes with the ability to deliver radiation damage across several cell diameters will compensate for less than perfect transduction efficiency.

REFERENCES:
Raben et al (1996) Gene Therapy 3:567-580.

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