Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-07-18
2006-07-18
Crouch, Deborah (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S325000, C435S455000
Reexamination Certificate
active
07078500
ABSTRACT:
Nucleic acid molecule that comprise a hepatitis C nonstructural protein including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising a hepatitis C nonstructural protein including a nucleotide sequence encoding NS3, NS4, or NS5, or a combination thereof, operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis C virus comprising administering such pharmaceutical compositions are disclosed.
REFERENCES:
patent: 5371017 (1994-12-01), Houghton et al.
patent: 5593972 (1997-01-01), Weiner et al.
patent: 5739118 (1998-04-01), Carrano et al.
patent: 5830875 (1998-11-01), Weiner et al.
patent: 6025341 (2000-02-01), Wands et al.
patent: 6297048 (2001-10-01), Jolly et al.
patent: 2002/0183508 (2002-12-01), Maertens et al.
patent: WO 96/13590 (1996-05-01), None
patent: WO 96/37606 (1996-11-01), None
patent: WO 96/38474 (1996-12-01), None
patent: WO 97/47358 (1997-12-01), None
patent: WO 99/29843 (1999-06-01), None
US 6,180,768, 01/2001, Maertens et al. (withdrawn)
Houghton. M Strategies and Prospects for Vaccination Against Hepatitis C (1999) in Current Topics in Microbiolgy and Immunology pp. 327-339.
Farci. P et al Prevention of hepatitis C infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope proteins (1996) PNAS 93 15394-99.
Selby et al Expression identification and subcellular localization of the protein encoded by the hepatitis C viral genome (1993) J Gen Virol 74 1103-1113.
D Souza et al In vitro cleavage of hepattitis C polyprotein substrates by purified recombinant NS3 protesase (1995) J Gen Virol 76 1729-36.
Harada et al Characterization of an established human hepatoma cell line constituitively expressing non-structural proteins of hepatitis C by transfection of viral cDNA (1995) J Gen Virol 76 1215-1221.
Hartikka et al. An improved plasmid DNA expression vector for direct injection into skeletal muscle (1996) Human Gene Therapy 7 1205-1217.
Selden RF, Transfection using DEAE dextran in Current Protocols in Molecular Biology Ausbel FM et al ed's (1987) John Wiley and Sons New York.
Chattergoon M et al. Genetic Immunization a new era in vaccines and immune therapeutics (1997) FASEB J 10 753-63.
McDonnell WM Molecular Medicine (1996) New Eng J Med. vol. 334, No. 1 42-45.
Encke et al., Genetic Immunization Generates Cellular and Humoral Immune Response . . . , 1998, pp. 4917-4923.
Kozak et al. (1999) Intiaition of translation in prokaryotes and eukaryotes GENE 234:187-208.
Lieto et al. (2003) Human CD94 Gene Expression:Dual Promoters Differing in Responsiveness to IL-2 or IL-15. J. Immunol. 171:5277-5286.
Martell, et al.; “Hepatitis C Virus (HCV) Circulates as a Population of Different but Closely Related Genomes: Quasispecies Nature of HCV Genome Distribution,”J. of Virol., 1992, vol. 66, No. 5, pp. 3225-3229.
Chisari, “Perspectives Series: Host/Pathogen Interactions,”,J. Clin. Invest., 1997, vol. 99, No. 7, pp. 1472-1477.
Rehermann, et al., Quantitative Analysis of the Peripheral Blood Cytotoxic T Lymphocyte Response in Patients with chronic Hepatitis C Virus Infection,J. Clin. Invest., 1996, vol. 98, No. 6, pp. 1432-1440.
Alter, et al., The Natural History of Community-Acquired Hepatitis C In The United States,The New England Journal of Medicine, 1992, vol. 327, No. 27, pp. 1899-1905.
Tsukuma, et al., “Risk Factors For Hepatocellular Carcinoma Among Patients With Chronic Liver Disease”,The New England Journal of Medicine, 1993, vol. 328, No. 25, pp. 1797-1801.
Xiang, et al., “Vaccination with a Plasmid Vector Carrying the Rabies Virus Glycoprotein Gene Induces Protective Immunity against Rabies Virus”;Virol., 1994, vol. 199, pp. 132-140.
Ulmer, et al., “Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein”,Science, 1993, vol. 259, pp. 1745-1749.
Wolff, et al., “Direct Gene Transfer into Mouse Muscle in Vivo,”Science, 1990, vol. 247, pp. 1465-1468.
Choo, et al., “Isolation of a cDNA Clone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome,”Science, 1989, vol. 244, pp. 359-362.
Wang, et al., “Gene Inoculation Generates Immune Responses Against Human Immunodeficiency Virus Type 1”;Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 4156-4160.
Bukh, et al., “Sequence Analysis of the 5′ Noncoding Region of Hepatitis C Virus,”Proc. Natl. Acad. Sci. USA, 1992, vol. 89, pp. 4942-4946.
Inchaupse, et al., “Genomic Structure of the Human Prototype Strain H of Hepatitis C Virus: Comparison With American and Japanese Isolates,”Proc. Natl. Acad. Sci. USA, 1991, vol. 88, pp. 10292-10292.
Choo, et al., “Genetic Organization and Diversity of the Hepatitis C Virus,”Proc. Natl. Acad. Sci. USA, 1991, vol. 88, pp. 2451-2455.
Han, et al., “Characterization of the Terminal Regions of Hepatitis C Viral RNA: Identification of Conserved Sequences in the 5′ Untranslated Region and Poly(A) Tails at the 3′ End,”Proc. Natl. Acad. Sci. USA, 1991, vol. 88, pp. 1711-1715.
Kato, et al. “Molecular Cloning of the Human Hepatitis C Virus Genome From Japanese Patients With Non-A, Non-B Hepatitis,”Proc. Nat'l. Acad. Sci., 1990, pp. 9524-9528.
Saito, et al., “Hepatitis C Virus Infection is Associated With The Development of Hepatocellular Carcinoma,”Proc. Natl. Acad. Sci. USA, 1990, vol. 87, pp. 6547-6549.
Manthorpe, et al., “Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice,”Vical, Inc., Human Gene Therapy, 1993, 4:419-431.
Heintges, et al., “Hepatitis C Virus: Epidemiology and Transmission,”Hepatology, 1997, vol. 26, No. 3, pp. 521-526.
Tokushige, et al., “Expression and Immune Response to Hepatitis C Virus Core DNA—Based Vaccine Constructs,”Hepatology, 1996, vol. 24, No. 1, pp. 14-20.
Ferrari, et al., “T-Cell Response to Structural and Nonstructural Hepatitis C Virus Antigens in Persistent and Self-limited Hepatitis C Virus Infections,”Hepatology, 1994, vol. 19, No. 2, pp. 286-295.
Kita, et al., “HLA B44-restricted Cytotoxic T Lymphocytes Recognizing an Epitope on Hepatitis C Virus Nucleocapsid Protein,”Hepatology, 1993, vol. 18, No. 5, pp. 1039-1044.
Simonetti, et al. “Hepatitis C Virus Infection as a Risk Factor for Hepatocellular Carcinoma in Patients with Cirrhosis,”Annals of Internal Medicine, 1992, vol. 116, No. 2, pp. 97-102.
Carithers, et al. “Therapy of Hepatitis C: Meta-analysis of Interferon Alfa-2b Trials,”Hepatology, 1997, vol. 26, No. 3, pp. 83S-88S.
Tascon, et al., “Vaccination Against Tuberculosis by DNA Injection,”Nature Medicine, 1996, vol. 2, No. 8, pp. 888-892.
Donnelly, et al., “Preclinical Efficacy of a Prototype DNA Vaccine: Enhanced Protection Against Antigenic Drift in Influenza Virus,”Nature Medicine, 1995, vol. 1, No. 6, pp. 583-587.
Diepolder, et al., “Possible Mechanism Involving T-lymphocyte Response to Non-Structural Protein 3 in Viral Clearance in Acute Hepatitis C Virus Infection,”The Lancet, 1995, vol. 346, pp. 1006-1007.
Boyer, et al. “Protection of Chimpanzees From High-Dose Heterologous HIV-1 Challenge by DNA Vaccination,”Nature Medicine, 1997, vol. 3, No. 5, pp. 526-532.
Tang, et al., “Genetic immunization is a simple method for eliciting an immune response,”Nature, 1992, vol. 356, pp. 152-154.
Wolff, et al., “Long-Term Persistence of Plasmid DNA and Foreign Gene Expression in Mouse Muscle,”Human Molecular Genetics, 1992, vol. 1, No. 6, pp. 363-369.
Wang, et al., “DNA Inoculation Induces Neutralizing Immune Responses Against Human Immunodeficiency Virus Type 1 in Mice and Nonhuman Primates,”DNA and Cell Biology, 1993, vol. 12, No. 9, pp. 799-805.
Fynan,
Encke Jens
Wands Jack
Crouch Deborah
Lieto Louis D
The General Hospital Corporation
Woodcock & Washburn LLP
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