Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1991-09-30
1993-06-22
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 693, 4351721, 4352521, 536 237, C12P 2102, C12N 1501, C12N 120, C07H 2100
Patent
active
052216187
ABSTRACT:
A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these toxin analogues are detoxified, retain an immunodominant S1 epitope, are immunogenic and are protective in the standard pertussis vaccine potency test in mice.
REFERENCES:
C. Locht et al. (1986) Science 232: 1258-1264.
A. Nicosia et al. (1986) Proc. Natl. Acad. Sci., USA 83: 4631-4635.
J. Mekalonos, et al. (1983) Nature 306: 551-557.
J. Kaper, et al. (1984) Nature 308: 655-658.
Boux Heather A.
Cockle Stephen A.
Klein Michel H.
Loosmore Sheena M.
Zealey Gavin R.
Bugaisky Gabriele E.
Connaught Laboratories Limited
Wax Robert A.
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