Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1988-11-23
1992-02-04
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4352523, 530350, 530387, 530403, 530405, 530406, A61K 3902
Patent
active
050858629
ABSTRACT:
A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this information, defined mutant holotoxins have been produced by site directed mutagenesis of the toxin gene. A number of these toxin analogues are detoxified, retain an immunodominant S1 epitope, are immunoganic and are protective in the standard pertussis vaccine potency test in mice.
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Boux Heather A.
Cockle Stephen A.
Klein Michel H.
Loosmore Sheena M.
Zealey Gavin R.
Connaught Laboratories Limited
Killos Paul J.
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