Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Reexamination Certificate
2006-09-12
2006-09-12
Swope, Sheridan L. (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
C435S191000, C435S252300, C435S252330, C435S254100, C435S254200, C435S419000
Reexamination Certificate
active
07105634
ABSTRACT:
Genes isolated fromMethylomonassp. 16a have been determined to play a role in the carotenoid biosynthetic pathway. Specifically, crtN2 gene has the ability to produce omega-aldehyde functional groups on carotenogenic substrates, while the ald gene produced omega carboxyl functional groups. These genes will be useful for production of high levels of functionalized carotenoid compounds, especially those produced in microorganisms which metabolize single carbon substrates.
REFERENCES:
patent: 5182208 (1993-01-01), Johnson et al.
patent: 5429939 (1995-07-01), Misawa et al.
patent: 5466599 (1995-11-01), Jacobson et al.
patent: 5530188 (1996-06-01), Ausich et al.
patent: 5530189 (1996-06-01), Ausich et al.
patent: 5545816 (1996-08-01), Ausich et al.
patent: 5656472 (1997-08-01), Ausich et al.
patent: 5691190 (1997-11-01), Girard et al.
patent: 5972642 (1999-10-01), Fleno et al.
patent: 6015684 (2000-01-01), Jacobson et al.
patent: 6124113 (2000-09-01), Hohmann et al.
patent: 2003/0003528 (2003-01-01), Brzostowics et al.
Galye et al, Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. Oct. 15, 1993;268(29):22105-11.
Whisstock et al, Prediction of protein function from protein sequence and structure. Q Rev Biophys. Aug. 2003;36(3):307-40. Review.
UniProt—03 database Acession No. DHAB—BACSU Nov. 1, 1997 from Boch et al., Synthesis of the osmoprotectant glycine betaine inBacillus subtilis: characterization of the gbsAB genes. J Bacteriol. Sep. 1996;178(17):5121-9. Alignment with SEQ ID No. 6.
Boch et al., Synthesis of the osmoprotectant glycine betaine inBacillus subtilis: characterization of the gbsAB genes. J Bacteriol. Sep. 1996;178(17):5121-9.
Lassner et al., Directed molecular evolution in plant improvement. Curr Opin Plant Biol. Apr. 2001;4(2):152-6. Review.
Nelis and Leenheer,Microbial sources of carotenoid pigments used in foods and feeds, Appl. Bacteriol. 70: 181-191, 1991.
Kushwaha, S.C. et al., Isolation and identification of dehydrosqualene and C40 Carotenoid Pigments in Halobacterium Cutirubrum, Biochim. Biophys Acta. vol. 260: pp. 492-506, 1972.
Armstrong, Eubacteria Show Their True Colors: Genetics of Carotenoid Pigment Biosyntehsis from Microbes to Plants, J. Bact. vol. 176: pp. 4795-4802, 1994.
Armstrong, Genetics of Eubacterial Carotenoid Biosynthesis: A Colorful Tale, Annu. Rev. Microbiol. vol. 51: pp. 629-659, 1997.
Farmer W. R. et al., Precursor Balancing for Metabolic Engineering of Lycopene Production inEscherichia coli, Biotechnol. Prog. vol. 17: pp. 57-61, 2001.
Wang C. et al., Directed Evolution of Metabolically EngineeredEscherichia colifor Cartenoid Production, Biotechnol. Prog. vol. 16: pp. 922-926, 2000.
Misawa, N. et al., Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts, J. Biotechnol. vol. 59: pp. 169-181, 1998.
Shimada, H. et al., Increased Carotenoid Production by the Food YeastCandida utilisthrough Metabolic Engineering of the Isopremoid Pathway. Appl. Environ. Microbiol. vol. 64: pp. 2676-2680, 1998.
Albrect, M. et al., Metabolic engineering of the terpenoid biosynthetic pathway ofEscherichia colifor production of the carotenoids □-carotene and zeaxanthin, Biotechnol. Lett. vol. 21: pp. 791-795, 1999.
Miura, Y. et al.,Production of the Carotenoids Lycopene □-Carotene, and Astaxanthin in the Food yeastCandida utilis, Appl. Environ. Microbiol. vol. 64: 1226-1229, 1998.
Kleinig, H. et al., New C30-Carotenoic Acid Glucosyl Esters fromPseudomonas rhodos. Z. Naturforsch 34c: pp. 181-185, 1979.
Kleinig, On the Biosynthesis of C30 Carotenoic Acid Glucosyl Esters inPseudomonas rhodos. Analysis of car-Mutants, Z. Naturforsch 37c: pp. 758-760, 1982.
Taylor, R. F. et al., Triterpenoid Carotenoids and Related Lipids, J. Biochem. vol. 139: 751-760, 1974.
Taylor, R. F., Bacterial Triterpenoids, Microbiol. Rev. vol. 48: pp. 181-198, 1984.
Takaichi, S. et al., The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4′-diaponeurosporene, not neurosporene. Arch. Microbiol. vol. 168: pp. 277-281, 1997.
Marshall, J. H. et al., Pigments ofStaphylococcus aureus, a Series of Triterpoenoid Carotenoids, J. Bacteriol., vol. 147: pp. 900-913, 1981.
Raisig et al., Functional properties of diapophytoene and related desaturases of C30 and C40 carotenoid biosynthetic pathways, Biochim. Biophys. Acta. vol. 1533: pp. 164-170, 2001.
Marshall, J. H. et al., Proposed Pathway of Triterpenoid Carotenoid biosynthesis inStaphylococcus aureus: Evidence from a Study of Mutants, J. Bacteriol. vol. 147: pp. 914-919, 1981.
Genbank Accession No. X73889, Wieland, B et al.,Staphylococcus aureus, Mar. 10, 2001.
Kuroda et al., Access No. AP003137,Staphyloccus aureussubsp. aureus N315, Jan. 11, 2003.
Kuroda et al.,Staphylococcus aureussubsp. aureus Mu50. Acc. No. AP003365, Feb. 7, 2002.
Raisig, A. et al., 4,4′Diapophytoene Desaturase: Catalytic Properties of an Enzyme from the C30 Carotenoid Pathway ofStaphylococcus aureus, J. Bacteriol. vol. 181(19): pp. 6148-6187, 1999.
Tippelt, A. et al., Squalene-hopene cyclase fromMethylococcus capsulantus(bath): a bacaterium producing hopanoids and steroids, Biochim. Biophys. Acta. 1391: pp. 223-232, 1998.
Xiong, J. et al., Tracking molecular evolution of photosynthesis by characterization fo a major photosynthesis gene cluster fromHeliobacillus mobilis, P. N. A. S. vol. 95, 6685, pp. 14851-14856, 1998.
Lin, X. et al.,Arabidopsis thaliana, Jan. 19, 2001, Cession No. AAG50992, Unpublished bg/aag50992.1/ac036.
Kuroda, M. et al., Whole genome sequencing of meticillin-resistantStaphylococcus aureus, Lancet 397. 9264, pp. 1225-1240, 1998.
Nakashima, T., et al., Cloning, Expression, and characterization of cDNAs encodingArabidopsis thalianasqualene synthase, PNAS, vol. 92: pp. 2328-2332, 1995.
Weiland et al., Genetic and BiochemicalAnalyses of the Biosynthesis of theYellow Carotenoid 4,4′-Diaponeurosporene ofStaphylococcus aureus, Journal of Bacteriology, Dec. 1994, 7719-7726.
Merkulov et al., Cloning and characterization of theYarrowia lipolyticasqualene synthase (SQSI) gene and functional complementation of theSaccharomyces cerevisiaeerg9 mutation, Yeast, vol. 16:pp. 197-206, 2000.
Umeno et al., Evolution of the C30- Carotenoid Synthase CrtM for unction in a C40 Pathway. Journal of Bacteriology, Dec. 2002, pp. 6690-6699, vol. 184, No. 23.
Cheng Qiong
Norton Kelley C.
Tao Luan
E. I. du Pont de Nemours and Company
Swope Sheridan L.
LandOfFree
Genetic constructs encoding carotenoid biosynthetic enzymes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genetic constructs encoding carotenoid biosynthetic enzymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetic constructs encoding carotenoid biosynthetic enzymes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3609102