Genetic construct of which protein coding DNA comprises introns

Details Genetic construct of which protein coding DNA comprises introns Genetic construct of which protein coding DNA comprises introns

1994-12-20

1997-07-22

Low, Christopher S. F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 232, 536 234, 536 2351, 536 231, 536 241, 536 242, 800 2, 4353201, 4351723, 4352402, 435 914, 4352523, 935 14, 935 22, 935 32, 935 70, 935 9, 935 10, 935 11, 935 13, C07H 2104

Patent

active

056505035

ABSTRACT:
Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5'-flanking sequence is sufficient to drive expression of the heterologous protein.

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