Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-11-04
1999-11-09
Guzo, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 74, 536 243, 536 2431, 536 2433, C12Q 168, C07H 2104
Patent
active
059811749
ABSTRACT:
Polymorphisms at positions 100, 271, 281, 294, 408, 506 or 1432 of the cytochrome P450 enzyme bufuralol-1'-hydroxylase are indicative of the extensive metaboliser/poor metaboliser phenotypes and can be detected using known methods such as amplification of the DNA with the polymerase chain reaction, followed by digestion with a suitable restriction enzyme and analysis by gel electrophoresis. The EM/PM phenotype is relevant to calculating safe or effective drug doses for individuals.
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Gough Alan Charles
Miles John Stephen
Spurr Nigel Kay
Wolf Charles Roland
Guzo David
Imperial Cancer Research Technology Limited
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