Genes which participate in .beta.-glucan assembly and use thereo

Details Genes which participate in .beta.-glucan assembly and use thereo Genes which participate in .beta.-glucan assembly and use thereo

1990-03-05

1993-03-16

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 29, 435 711, 935 37, 935 69, C12Q 168, C12Q 102, C12P 2104, C07H 1906

Patent

active

051946009

ABSTRACT:
The present invention relates to DNA sequences coding for genes which participate in a yeast cell wall .beta.-glucan assembly pathway. These genes are essential for normal cell growth and are tools whicn enable the `in vitro` or `in vivo` screening for differential inhibition of fungi pathogenic to plants and animals, including man by specific antifungal agents. Further, a method which allows one to produce structurally modified glucans by using the DNA sequences of the present invention is also provided. Such modified glucans can be used to facilitate protein extraction from a microorganism; as food additives or as immunomodulators. Also, a method for selecting yeast mutants resistant to killer toxins from other yeasts or fungi which comprises exposing sensitive yeast cells to such killer toxins on agar plates, and selecting for yeast cells that survived such exposure by their ability to grow and form colonies.

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Manners, D. J. et al., Biochem. J., 1973, 135: 19-30.
Manners, D. J. et al., Biochem. J., 1973, 135: 31-36.
Hutchins K. & Bussey, H. J. Bacteriol., 1983, 154: 161-169.
Roncero et al. J of Bact. 170(4): 1950 (1988).
Bonne Abs. Thesis disert. 51/09-B: 4144 (1989).

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