Genes involved in the molecular paths of tumor suppression...

Details Genes involved in the molecular paths of tumor suppression... Genes involved in the molecular paths of tumor suppression...

2005-10-18

2005-10-18

Shukla, Ram R. (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000

Reexamination Certificate

active

06956110

ABSTRACT:
The invention concerns genes involved in the molecular paths for tumor suppression and/or resistance to viruses, and whereof the cell expression is in particular induced or inhibited during apoptosis and/or tumor suppression.

REFERENCES:
patent: 95/20654 (1995-08-01), None
patent: 97/22695 (1997-06-01), None
Roperch et al. SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21Waf1. Proc. Natl. Acad. Sci. USA 96:8070-8073, 1999.
Advani et al. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J of Biological Chemistry 273:10317-10324, 1998.
Robert B. Amson, et al.; “Isolation of 10 Differentially Expressed cDNAs in P53-Induced Apoptois: Activation of the Vertebrate Homologue of theDrosophilaSeven in Absentia Gene”; Proc. Nat'l Acad. Sci. USA, vol. 93, pp. 3953-3957; Apr. 1996.
Robert Strausberg, Ph.D.; “EST. H. Sapiens cDNA Clone Image: 1556458”; Database GENBANK 'Online!; Accession No. AA935282; Jun. 23, 1998.
Robert Strausberg, Ph.D.; “EST. H. Sapiens cDNA Clone Image: 1650253, Similar to T-complex Protein 1 (TCP-1) Epsilon Subunit”, Database GENBANK 'Online!; Accession No.A1022498; Jun. 19, 1998.
Mona Nemani et al.; “Activation of the Human Homologue of theDrosophia sinaGene in Apoptosis and Tumor Suppression”; Proc. Nat'l Acad. Sci. USA, vol. 93, pp. 9039-9042, Aug. 1996.
Jean-Peierre Roperch, et al.; “Inhibition of Presenilin 1 Expression is Promoted by p. 53 and p. 21 WA-WAF-1and Results in Apoptosis and Tumor Suppression”, Nature Medicine, vol. 4, No. 7, pp. 835-838, Jul. 1998.
David Israeli, et al.; “A Novel p. 53-Inducible Gene, PAG608, Encodes a Nuclear Zinc Finger Protein Whole Overexpression Promotes Apoptosis”; The EMBO Journal, vol. 16, No. 14, pp. 4384-4392, 1997.
Gustavo Linares-Cruz, et al.; “p. 21WAF-1Reorganizes the Nucleus in Tumor Suppression”; Proc. Nat'l Acad. Sci. USA; vol. 95, pp. 1131-1135, Feb. 1998.

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