Genes involved in isoprenoid compound production

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S183000, C435S067000, C435S252300, C435S320100, C435S069100, C435S071100, C435S410000, C435S415000, C435S419000, C435S243000, C435S253100, C536S023200, C536S023700

Reexamination Certificate

active

07056717

ABSTRACT:
Genes have been isolated fromMethylomonas16a sp. encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from aMethylomonasstrain that is capable of utilizing single carbon (C1) substrates as energy sources. The genes and gene products of the present invention may be used in a variety of ways for the production of isoprenoid compounds in a variety of organisms.

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Sequence Alignment.
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Cunningham et al., Evidence of Role for LytB in the Nonmevalonate Pathway of Isoprenoid, Biosynthesis. J. of Bacteriol. 182: 5841-5848, 2000.
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Rohdich et al., Cytidine 5'-triphosphate-dependent biosynthesis of Isoprenolds:, Proc. Natl. Acad. Sci. USA Oct. 12, 1999: 98 (21):11758-63.
Herz et al., Biosynthesis of terpenoids, YgbBprotein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erthritol 2,4-cyclodiphosphate, Proc. Natl. Acad. Sci. USA, Mar. 14, 2000: 97(6):2486-90.
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Xiong, et al., Tracking molecular evolution of photosynthesis by characterization of a major photosynthesis gene cluster from helio

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