Genes for the synthesis of pyrrolnitrin

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352523, 43525233, 4351723, 435117, 435 691, 435 711, 4353201, 536 232, 536 237, C12N 120

Patent

active

058175024

ABSTRACT:
The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

REFERENCES:
patent: 4306027 (1981-12-01), Alexander et al.
patent: 4456684 (1984-06-01), Weller et al.
patent: 4695455 (1987-09-01), Barnes et al.
patent: 4729951 (1988-03-01), Ferenczy et al.
patent: 4798723 (1989-01-01), Dart et al.
patent: 4812512 (1989-03-01), Lopez Bernestein et al.
patent: 4880745 (1989-11-01), Kijima et al.
patent: 4940840 (1990-07-01), Suslow et al.
patent: 4948413 (1990-08-01), Maekawa et al.
patent: 4952496 (1990-08-01), Studier et al.
patent: 4970147 (1990-11-01), Huala et al.
patent: 4975277 (1990-12-01), Janisiewicz et al.
patent: 4994495 (1991-02-01), Clough et al.
patent: 4999381 (1991-03-01), Crowley et al.
patent: 5008276 (1991-04-01), Clough et al.
patent: 5041290 (1991-08-01), Gindrat et al.
patent: 5049379 (1991-09-01), Handelsmon et al.
patent: 5059605 (1991-10-01), Clough et al.
patent: 5068105 (1991-11-01), Lewis et al.
patent: 5279951 (1994-01-01), Terasawa et al.
Albright et al., Annu. Rev. Genet., 23:311-336 (1989).
Baker et al., Biological Control of Plant Pathogens, 61-106 (American Phytopathological Society, St. Paul, Minn. 1982).
Bourret et al., Annu. Rev. Biochem., 60:401-441 (1991).
Brisbane et al., Antimicrobiol. Agents and Chemotherapy, 31(12):1967-1971 (1987).
Brisbane et al., Soil Biol. Biochem., 21(8):1019-1026 (1989).
Chen et al., "Cloning and Expression of a DNA Sequence Conferring Cephamycin C Production", Biotechnology, 6(10):1222-1224 (1988).
Clarke et al., J. Bacteriol. 154:508-512 (1983).
Cook et al., Soil Biol. Biochem., 8:269-273 (1976).
Ding et al., Gene, 33(3):212-321 (1985).
Ditta et al., PNAS:USA, 77:7347-7351 (1980).
Gaffney et al., "Global Regulation of Expression of Antifungal Factors by Pseudomonas fluorescens biological Control Strain", Molecular Plant-Microbe Interactions, 7(4):455-463 (1994).
Gaffney et al., MPMI, 7(4):455-463 (1994).
Gambello et al., J. Bacteriology, 173(9): 3000-3009 (1991).
Gurusiddaiah et al., Antimicrobiol. Agents and Chemotherapy, 79(3): 488-495 (1986).
Gutterson et al., Journal of Bacteriology, 165(3):696-703 (1986).
Hain et al., "Disease resistance results from foreign phytoalexin expression in a novel plant", Nature 361:153-156 (1993).
Hamdan et al., Applied and Environ. Microbiol. 57:3270-3277 (1991).
Horn et al., J. Bacteriology, 170(10):4699-4705(1988).
Howell et al., Can. J. Microbiol., 29:321-324 (1983).
Howell et al., Phytopathology, 69(5):480-482 (1979).
Howell et al., Phytopathology, 69:480-482 (1979).
Howell et al., Phytopathology, 70:712-715 (1980).
Howie et al., Phytopathology, 79(10):1160 (1989).
Inouye et al., J. Bacteriology, 155(3):1192-1199 (1983).
James et al., Applied and Environmental Microbiology, 52(5):1183-1189 (1986).
Jayaswal et al., Can. J. Microbiol., 38(4):309-312 (1992).
Jeenes et al., Mol. Gen. Genet., 203:421-429 (1986).
Kaphammer et al., J. Bacteriology, 172(10):5856-5862 (1990).
Keel et al., Symbiosis, 9(1-3):327-341 (1990).
Kirner et al., Microbiology, 142:2129-2135 (1996).
Klee et al., The Plant Cell, 3:1187-1193 (1991).
Kloepper et al., Phytopathology, 71:1020-1024 (1981).
Kraus et al., Phytopathology, 79(8):910 (1989).
Kroos et al., PNAS USA, 81:5816-5820 (1984).
Lam et al., "Genetic regulation of biocontrol factors in Pseudomonas fluorescens", Third International Workshop on Plant-Promoting Rhizobacteria, Australia 97-99 (1994).
Laville et al., PNAS USA, 89:1562-1566 (1992).
Lievens et al., Pesticide Science, 27(2):141-154 (1989).
Loper, Phytopathology, 78:166-171 (1988).
Maruzen Oil Abstract, 27 (1979).
Mekalanos, J.J., J. Bacteriology, 174:1-7 (1992).
Mermod et al., J. Bacteriology, 167(2):447-454 (1986).
Mohr et al., Molecular Microbiology, 4(12):2103-2110 (1990).
Moolenaar et al., Nucl. Acids Res., 15(10):4273-4289 (1989).
Orlik-Eisel et al., Microbiology, 153(6):561-568 (1990).
Pfender et al., Phytopathology, 83:1223-1228 (1993).
Ramos et al., Science, 235(4788):593-596 (1987).
Rothmel et al., J. Bacteriology, 173(15):4717-4724(1991).
Schell, M.A., Gene, 36(3):301-309 (1985).
Scher et al., Phytopathology, 70:412-417 (1980).
Schroth et al., Science, 216:1376-1381 (1982).
Spena et al., Mol. Gen. Genet., 227:205-212 (1991).
Starnbach et al., Molecular Microbiology, 6(4):459-469 (1992).
Stock et al., Microbiological Reviews, 53(4): 450-490 (1989).
Tanaka et al., J. Bacteriology, 170(8):3593-3600 (1988).
Thomashow et al., J. Bacteriology, 170:3499-3508 (1988).
Toder et al., Molecular Microbiology, 5(8):2003-2010 (1991).
Toohey et al., "Toxicity of Phenazine Carboxylic Acids to Some Bacteria, Algae, Higher Plants, and Animals", Canadian Journal of Botany, 43:1151-1155 (1965).
Weller et al., Journal of Cellular Biochemistry, Supplement 13A: 134, Abstract CB104 (1989).
Weller et al., Phytopathology, 73:463-469 (1983).
"Nikkomycin-Antibiotic for Plants", NTIS Tech Notes, 5:374 (1990) European Search Report dated Sep. 28, 1995.
Hoffmann-LaRoche & Co., "Phenazine Derivatives and a Process for the Manufacture Thereof", GB-A-1 285 010 Patent Specification, 1-8 (1972).
Wolffram et a. "Cloning and high-level expression of a chloroperoxidase gene . . . " FEBS Letters 238, 325-328, Oct. 1988.
Wiesner et al. "Purification and characterization of a novel bacterial non-heme chloroperoxidase . . . " J. Biol. Chem. 263, 13725-13732, Sep. 1988.
VanPee, K. "Bacterial Haloperoxidases and other role in secondary metabolism" Biotech. Adv. 8, 185-205, 1990.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Genes for the synthesis of pyrrolnitrin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genes for the synthesis of pyrrolnitrin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes for the synthesis of pyrrolnitrin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-76134

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.