Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-03-31
1997-07-01
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 43525233, 4353201, 536 237, C12N 1531, C12N 1574, C12N 121, C07H 2104
Patent
active
056437471
ABSTRACT:
The invention relates to a cloned region of the Bordetella pertussis genome located 3' of the ptx operon encoding factors required for expression, assembly and secretion of pertussis holotoxin. Methods for obtaining increased levels of holotoxin production using homologous and heterologous hosts are also described.
REFERENCES:
patent: 5380653 (1995-01-01), Palva
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A Covacci and R. Rappuoli, "pertussis Toxin Export Requires Accessory Genes Located Downstream From The pertussis Toxin Operon", Molecular Microbiology 8(3):429-434, (1993).
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Shirasu, et al., "The virB Operon of the Agrobacterium tumefaciens Virulence Regulon has Sequence . . . ", Nucleic Acids Research, 21:353-354 (1993).
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Baker Steven M.
Deich Robert A.
American Cyanamid Company
Chambers Jasemine C.
Priebe Scott D.
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