Chemistry: molecular biology and microbiology – Plant cell or cell line – per se ; composition thereof;... – Plant cell or cell line – per se – contains exogenous or...
Patent
1996-12-14
1998-02-10
Wax, Robert A.
Chemistry: molecular biology and microbiology
Plant cell or cell line, per se ; composition thereof;...
Plant cell or cell line, per se, contains exogenous or...
4352523, 43525231, 43525232, 43525233, 4353201, 536 231, 536 232, 536 237, C12N 120
Patent
active
057168490
ABSTRACT:
The present invention is directed to the production of a polyketide antibiotic such as soraphen in a host via recombinant expression of the polypeptides needed to biologically synthesize the polyketide antibiotic. Polyketide synthase (PKS) genes encoding polypeptides necessary to synthesize soraphen are provided, along with methods for identifying and isolating the PKS genes needed to recombinantly biosynthesize any desired polyketide antibiotic. The cloned PKS genes may be transformed and expressed in a desired host organisms to produce soraphen for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of soraphen.
REFERENCES:
Gerth et al., "The Soraphens: A Family of Novel Antifungal Compounds From Sorangium cellulosum (Myxobacteria)", The Journal of Antibiotics, 47(1):23-31 (1994).
Jaoua et al., "Transfer of Mobilizable Plasmids to Sorangium cellosum and Evidence for Their Integration into the Chromosome", Plasmid, 28: 157-165 (1992).
Schupp et al., "A Sorangium cellulosum (Myxobacterium) Gene Cluster for the Biosynthesis of the Macrolide Antibiotic Soraphen A: Cloning, Characterization, and Homology to Polyketide Synthase Genes from Actinomycetes", Journal of Bacteriology, 177 (13): 3673-3679 (1995).
Beck James J.
Hill Dwight S.
Ligon James M.
Neff Snezana
Ryals John A.
Meigs J. Timothy
Nashed Nashaat T.
Novartis Finance Corporation
Wax Robert A.
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