Genes for the biosynthesis of epothilones

Details Genes for the biosynthesis of epothilones Genes for the biosynthesis of epothilones

2005-02-22

2005-02-22

Nashed, Nashaat T. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

C435S076000, C435S183000, C536S023200

Reexamination Certificate

active

06858404

ABSTRACT:
Nucleic acid molecules are isolated fromSorangium cellulosumthat encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

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