Genes for the biosynthesis of epothilones

Details Genes for the biosynthesis of epothilones Genes for the biosynthesis of epothilones

1999-06-17

2000-09-19

Nashed, Nashaat T.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435232, 435193, 435189, 4352523, 43525235, 4353201, 530300, 536 232, 536 237, 536 231, C12N 900, C12N 120, C07H 2104

Patent

active

061210293

ABSTRACT:
Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

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