Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Reexamination Certificate
2006-05-16
2006-05-16
Kemmerer, Elizabeth (Department: 1649)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
C800S018000, C435S354000, C435S007210, C435S069100, C435S252300, C435S455000, C435S463000, C530S300000, C530S350000, C514S002600, C536S023500
Reexamination Certificate
active
07045675
ABSTRACT:
A gene for type C Niemann-Pick disease (NP-C) is disclosed, along with the amino acid sequence of the encoded peptide. Applications which are made possible by the present invention include detection of NP-C carriers and diagnosis of NP-C sufferers. The murine ortholog of the human gene is also disclosed.
REFERENCES:
patent: 4039388 (1977-08-01), Gal et al.
patent: 5859328 (1999-01-01), Nasrallah et al.
patent: 6426198 (2002-07-01), Carstea et al.
patent: 0 520 843 (1992-04-01), None
Wallace et al. (in Berger and Kimmel, Eds., Methods in Enzymology, 152(432-442)1987).
Sambrook et al., Molecular Cloning, p. 11.47, 1989.
Bowie et al., 1990, Science 247:1306-1310.
Alexander et al., Proc. Natl. Acad. Sci. 89(3352-3356)1992.
Hillier et al., EMBL Accession W53013, Oct. 10, 1996.
“Genetic Diseases of Recognized Biochemical Abnormality,”Merritt's Textbook of Neurology, Eight Edition, p. 508, 1989.
Brady et al, “Niemann-Pick Disease Types C and D,”Neurologic Clinics, vol. 7, No. 1, p. 75-87, Feb. 1989.
“Nieman-Pick Disease,”Neurology in Clinical Practice, vol. II, p. 1316, 1991.
Carstea et al., “Linkage of Niemann-Pick disease type C to human chromosome 18,”Proc. Natl. Acad. Sci. USA, 90:2002-2004, Mar. 1993.
Carstea et al., “Localizing the human Nieman-Pick C gene to 18q11-12,”Am. J. Hum. Genet., vol. 55, No. 3, p. A182, Sep. 1994.
Vanier et al., “Genetic Heterogeneity in Niemann-Pick C Disease: A Study Using Somatic Cell Hybridization and Linkage Analysis,”Am. J. Hum. Genet.58:118-125, 1996.
L. Hiller et al., “The WashU-Merck EST project, zc02h09.r1 Soares parathyroid tumor NbHPA Homo sapiens cDNA clone 321185 5′,” EMBL Database Entry HS013342, Accession No. W53013, XP002078611, Jun. 4, 1996.
M. Marra et al, “The Wash-HHMI Mouse EST project. Md15d07.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA clone 368461 5′,” EMBL Database Entry MM72024, Accession No. W53720, XP002078612, Jun. 6, 1996.
Gu et al., “Substantial narrowing of the Niemann-Pick C candidate interval by yeast artificial chromosome complementation,”Proc. Natl. Acad. Sci. USA, 94:7378-7383, Jul. 1997.
Loftus et al., “Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene,”Science, 277:232-235, Jul. 11, 1997.
Carstea et al., “Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis,”Science, 277:228-231, Jul. 11, 1997.
Carstea et al., “Newfound Gene Holds Key to Cell's Cholesterol Traffic,”Science, 277:180-181, Jul. 11, 1997.
Bowie et al.,Science247:1306-1310, 1990.
Carstea et al.,Science277:228-231, 1997.
GenBank Accession No. H11606, 1995.
Ngo et al., The Protein Folding Problem and Tertiary Structure, pp. 492-495, 1994.
Wells,Biochemistry, 29:8509-8517, 1990.
Miyawaki et al., Sphingomyelinosis, a New Mutation in the Mouse: A Model of Niemann-Pick Disease in Human,J. Hered., 73:257-263, 1982.
Morris et al., Lysosome Lipid Storage Disorder in NCTR-BALB/c Mice. I. Description of the Disease and Genetic,Am. J. Pathol., 108:140-149, 1982.
Ohno et al., A Cell Line Derived from Sphingomyelinosis Mouse Shows Alterations in Intracellular Cholesterol Metabolism Similar to Those in Type C Niemann-Pick Disease,Cell Structure&Function, 17:229-235, 1992.
Sakiyama et al., A Lysosomal Storage Disorder in Mice: A Model of Niemann-Pick Disease,J. Inherited Metab. Dis., 5:239-240, 1982.
Erickson et al., High Resolution Mapping of thespm(Neimann-Pick Type C) Locus on Mouse Chromosome 18,Mamm. Genome, 8(5):355-356, May 1997.
Ashlock Melissa A.
Carstea Eugene D
Gu Jessie
Loftus Stacie K.
Morris Jill A.
Brannock Michael
Kemmerer Elizabeth
Klarquist & Sparkman, LLP
The United States of America as represented by the Department of
LandOfFree
Genes for Niemann-Pick type C disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genes for Niemann-Pick type C disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes for Niemann-Pick type C disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3649444