Genes for biologically active proteins

Details Genes for biologically active proteins Genes for biologically active proteins

1986-02-06

1989-07-18

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4351723, 435320, 435 91, 4353171, 935 6, 935 8, 935 9, 935 10, 935 11, 935 29, C12N 1500, C12N 100, C12P 2100

Patent

active

048493490

ABSTRACT:
The cDNA of a new proteinase inhibitor was isolated from a cDNA library of human liver biopsy material using a synthetic Oligonucleotide probe. The cDNA can be expressed by introduction of the cDNA to a microbial host on a DNA vector. Analogs of known proteinase inhibitors can be producing by alteration of the cDNA by substituting codons in the active center of the new proteinase inhibitor.

REFERENCES:
Chandra et al., Proc. Natl. Acad. Sci., vol. 80, 1845-1848, Apr. 1983.
Rosenberg et al., Nature, vol. 312 1, pp. 76-88, Nov. 1984.
Kurachi et al., Proc. Natl. Acad. Sci., vol. 78 11, pp. 6826-6830, Nov. 1981.
Stackhose, R. et al., "Purification of Antithrombin III mRNA and Cloning of Its cDNA", J. Biol. Chem. 258:703-706, 1982.
Witt, I. et al., "Amino Acid Composition and N-Terminal Sequence of Antithrombin BM", Thrombosis Research 32:513-518, 1983.
Courtney, M. et al., "Synthesis in E. coli of 1-Antitrypsin Variants of Therapeutic Potential for Emphysema and Thrombosis", Nature 313: 149-151.

Affiliated with

Also associated with

Rating

Genes for biologically active proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genes for biologically active proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes for biologically active proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-171821