Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-12-17
1996-01-23
Fleisher, Mindy B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435226, C12N 1558, C12N 964
Patent
active
054866022
ABSTRACT:
The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
REFERENCES:
patent: 5108901 (1992-04-01), Anderson
Rickles et al., J. Biol. Chem., 263:1563-1569 (1988).
Ny et al., DNA, 7:671-677 (1988).
Gardell et al., J. Biol. Chem., 264:17947-17952 (1989).
Strassburger et al., FEBS, 157:219-223 (1983).
Peterson et al., Biochemistry, 29:3451-3457 (1990).
Gething Maryjane H.
Goldsmith Elizabeth J.
Madison Edwin L.
Sambrook Joseph F.
Fleisher Mindy B.
The Board of Regents of the University of Texas System
Vogel Nancy T.
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