Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-10
2007-07-10
Ulm, John (Department: 1649)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S007210, C435S069100, C435S252300, C435S320100
Reexamination Certificate
active
10183708
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding an insect odorant receptor. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically hybridizing with the nucleic acid molecule encoding an insect odorant receptor. This invention also provides a purified, insect odorant receptor. This invention provides an antibody capable of specifically binding to an insect odorant receptor. This invention provides a method for identifying cDNA inserts encoding an insect odorant receptors. This invention provides a method of identifying a compound capable of specifically bind to an insect odorant receptor. This invention also provides a method of identifying a compound capable of activating the activity of an insect odorant receptor.
REFERENCES:
patent: WO 00/43410 (2000-06-01), None
patent: 0043410 (2000-07-01), None
Ben-Arie, N., Lancet, D., Taylor, C., Kehn, M., Walker, N., Ledbetter, D.H., Carrozzo, R., Patel, K., Sheer, D., Lehrach, H., and et al., (1994) Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Hum. Mol. Genet. 3: 229-235.
Bowie, James U., Reidhaar-Olson, J.F. (1990) Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science 247: 1306-1310.
Buck, L. and Axel, R. (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 65: 175-187.
Carlson, JR. (2001) Functional expression of a Drosophila odor receptor. Proc. Natl. Acad. Sci. 98(16): 8936-8937.
Doe, C. Q., and Skeath, J.B. (1996) Neurogenesis in the insect central nervous system. Curr.Opin. Neurobiol. 6:18-24.
Dulac, C., and Axel, R. (1995) A novel family of genes encoding putative pheromone receptors in mammals. Cell. 83: 195-206.
Faber, T., Joerges, J., and Menzel, R. (1998) Associative learning modifies neural representations of in the insect brain. Nature Neurosci. 2: 74-78.
Gao, Q. et al. (Jul. 1999) Identification of candidate olfactory receptors from genomic DNA sequence. Genomics 60: 31-39.
Gimelbrandt, A.A. et al. (Feb. 1999) Truncation releases olfactory receptors from endoplasmic reticulum of heterologous cells. J. Neurochem. 72(6): 2301-2311.
Grillenzoni, N., van Helden, J., Dambly-Chaudiere, C., and Ghysen, A. (1998) The iroquois complex controls the somatotopy of Drosophila notum mechanosensory projections. Development 125: 3563-3569.
Herrada, G., and Dulac, C. (1997) A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Cell 90:763-773.
Kim, M. S., Repp, A., and Smith, D.P. (1998) LUSH odorant-binding protein mediates chemosensory responses to alcohols inDrosophila melanogaster. Genetics 150: 711-721.
Levy, N.S., Bakalyar, H.A., and Reed, R.R. (1991) Signal transduction in olfactory neurons. J. Steroid Biochem. Mol. Biol. 39: 633-637.
Matsunami, H., and Buck, L.B. (1997) A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 90: 775-784.
Mckenna, M.P., Hekmat-Scafe, D.S., Gaines, P., and Carlson, J.R. (1994) PutativeDrosophilapheromone-binding proteins expressed in a subregion of the olfactory system. J. Biol. Chem. 269: 16340-16347.
Merrit, D. J., and Whitington, P.M. (1995) Central projections of sensory neurons in theDrosophilaembryo correlate with sensory modality, soma position, and proneural gene function. J. Neurosci. 15:1755-1767.
Ngo, J.T., Marks, J., Karplus, M. (1994) Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox. In: Merz, K. Jr. and Le Grand, S. (Eds) The Protein Folding Problem and Tertiary Structure, Chapter 14, pp. 492-495, Birkhäuser, Boston.
Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S., Lefort, A., Eggericks, D., Ledent, C., Molleareau, C., Gerard, D., and et al. (1992) Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature, 355:453-455.
Pelosi, P. (1994) Odorant-binding proteins. Crit. Rev. Biochem. Mol. Biol. 29: 199-228.
Pikielny, C.W., Hasan, G., Rouyer, F., and Rosbash, M. (1994) Members of a family ofDrosophilaputative odorant-binding proteins are expressed in different subsets of olfactory hairs. Neuron. 12: 35-49.
Robertson, H.M. (1998) Two large families of chemoreceptor genes in the nematodesCaenorhabditis elegansandCaenorhabditis briggsaereveal entensive gene duplication, diversification, movement , and intron loss. Genome Res. 8: 449-463.
Ryba, N.J., and Tirindelli, R. (1997) A new multigene family of putative pheromone receptors. Neuron 19: 371-379.
Stocker, R.F. (1994) The organization of the chemosensory system inDrosophila melanogaster: a review. Cell Tissue Res. 275: 3-26.
Störtkuhl, K.F. and Kettler, R. (2001) Functional analysis of an olfactory receptor inDrosophila melanogaster. Proc. Natl. Acad. Sci. 98(16):9381-9385.
Troemel, E.R., Chou, J. H., Dwyer, N.D., Colbert, H. A., and Bargmann, C.I. (1995) Divergent seven transmembrane receptors are candidate chemosensory receptors inC. elegans. Cell. 83: 207-218.
Vosshall, L.B. et al. (Mar. 5, 1999) A spatial map of olfactory receptor expression in theDrosophilia antenna. Cell 96: 725-737.
Wells, J.A. (1990) Additivity of mutational effects in proteins. Biochemistry 29:8509-8517.
Wetzel, C.H. et al. (2001) Functional expression and characterization of aDrosophilaodorant receptor in a heterologous cell system. Proc. Natl. Acad. Sci. 98(16):9381-9385.
Supplementary Partial European Search Report Under Rule 46(1) EPC issued in connection with related European Patent Application No. 00915898.1, on behalf of The Trustees of Columbia University in the City of New York, regional stage of PCT International Application No. PCT/US00/04995, filed Feb. 25, 2000.
Carlson, J.R., “Olfaction inDrosophila: from odor to behavior,” Trends in Genetics, vol. 12, No. 5, pp. 175-180 (May 1996).
Clyne, P.J., et al., “A novel family of divergent seven-transmembrane proteins: candidate odorant receptors inDrosophila,” Neuron, vol. 22, No. 2, pp. 327-338 (Feb. 1999).
Supplementary Partial European Search Report Under Rule 45 EPC issued in connection with related European Patent Application No. 00915898.1, on behalf of The Trustees of Columbia University in the City of New York, regional stage of PCT International Application No. PCT/US00/04995, filed Feb. 25, 2000.
Database EMBL ‘Online’, Accession No. CNS00ZH7 (Jul. 26, 1999).
Amrein Hubert O.
Axel Richard
Vosshall Leslie B.
Cooper & Dunham LLP
The Trustees Of Columbia University In The City Of New York
Ulm John
White John P.
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