Genes encoding caspase recruitment domain polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387300, C530S388100, C530S388800, C530S389100

Reexamination Certificate

active

07057021

ABSTRACT:
The invention relates to nucleic acid molecules encoding CARD-3, nucleic acid molecules encoding CARD-4, CARD-3 polypeptides, CARD-4 polypeptides, and uses thereof.

REFERENCES:
patent: WO 98/55507 (1998-12-01), None
McCarthy et al., “RIP2 is a novel NF-kB-Activating and cell death-inducing kinase” J. of Bi l. Chem. 273(27):16968-16975, 1998.
Yan et al., “mE10, a novel caspase recruitment domain-containing prospoptotic molecule” J. of Bi l Chem. 274(15):10287-10292, 1999.
Baker et al., “Transducers of Life and Death: TNF Receptor Superfamily and Associated Protein”, Oncogen 12:1-9, 1996.
Chinnaiyan et al., “The Cell-death Machine”, Current Biology 6:555-562, 1996.
Duan et al., “RAIDD is a New ‘Death’ Adaptor Molecule”, Nature 385:86-89, 1997.
Hofmann et al., “The CARD Domain: A New Apoptotic Signalling Motif”, TIBS 22:155-156, 1997.
Li et al., “Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade”, Cell 91:479-489, 1997.
Miura et al., “Induction of Apoptosis in Fibroblasts by IL-1β-Converting Enzyme, a Mammalian Homolog of C. Elegans Cell Death Gene ced-3”, Cell 75:653-660, 1993.
Reed, “Cytochrome c: Can't Live with It—Can't Live without It”, Cell 91:559-562, 1997.
Wallach, “Cell Death Induction by TNF: A Matter of Self Control”, TIBS 22:107-109, 1997.

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