Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-02-06
2000-03-07
Brusca, John S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 4353201, 435325, 536 231, 536 235, 536 243, C07H 2102, C07H 2104, C12N 1500, C12N 1563, C12N 168
Patent
active
060338555
ABSTRACT:
The invention relates to nucleic acid molecules encoding CARD-3, nucleic acid molecules encoding CARD-4, CARD-3 polypeptides, CARD-4 polypeptides, and uses thereof.
REFERENCES:
Baker et al., "Transducers of Life and Death: TNF Receptor Superfamily and Associated Protein", Oncogene 12:1-9, 1996.
Chinnaiyan et al., "The Cell-death Machine", Current Biology 6:555-562, 1996.
Duan et al., "RAIDD is a New `Death` Adaptor Molecule", Nature 385:86-89, 1997.
Li et al., "Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade", Cell 91:479-489, 1997.
Miura et al., "Induction of Apoptosis in Fibroblasts by IL-1.beta.-Converting Enzyme, a Mammalian Homolog of the C. Elegans Cell Death Gene ced-3", Cell 75:653-660, 1993.
Reed, "Cytochrome c: Can't Live with It--Can't Live without It", Cell 91:559-562, 1997.
Wallach, "Cell Death Induction by TNF: A Matter of Self Control", TIBS 22:107-109, 1997.
Hofmann et al., "The CARD Domain: A new apoptotic signalling motif" TIBS 22:155-156, 1997.
McCarthy et al., "RIP2 is a novel NF-kB-Activating and cell death-inducing kinase" J. of Biol. Chem. 273(27):16968-16975, 1998.
Yan et al., "mE10, a novel caspase recruitment domain-containing proapoptotic molecule" J. of Biol Chem. 274(15):10287-10292, 1999.
Hillier et al. Databases EMBL and GenBank on MPSRCH accession No. AA160647, Dec. 1996.
Hillier et al. Databases EMBL and GenBank on MPSRCH accesion No. AA160649, Dec. 1996.
Hillier et al. Databases EMBL and GenBank on MPSRCH accesion No. AA723533, Jan. 1998.
Brusca John S.
McGarry Sean
Millennium Pharmaceuticals Inc.
LandOfFree
Genes encoding caspase recruitment domain polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genes encoding caspase recruitment domain polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes encoding caspase recruitment domain polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-361460