Genes encoding a novel family of potassium channels

Details Genes encoding a novel family of potassium channels Genes encoding a novel family of potassium channels

1994-10-31

1996-09-24

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

4353201, 536 235, C12N 114, C12N 1500, C07H 2104

Patent

active

055590268

ABSTRACT:
A first aspect of the present invention is the isolation and characterization of invertebrate (i.e. insect and nematode) potassium channel genes. The present invention provides for the isolation of complementary DNA fragments from Drosophila melanogaster and Caenorhabditis elegans which encode conserved amino acid sequence elements unique to the potassium channel gene family. A yeast expression technology is employed to clone cDNAs from Drosophila melanogaster and a hybridization approach is utilized to isolate additional cDNAs from Caenorhabditis elegans. Using the yeast expression technology, a single 2463 base pair cDNA fragment designated Dm ORF1 is isolated.

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Zhou et al. (1995) FEBS Letters 373: 170-176.

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