Genes encoding a 3-acylation enzyme for macrolide antibiotics

Details Genes encoding a 3-acylation enzyme for macrolide antibiotics Genes encoding a 3-acylation enzyme for macrolide antibiotics

1991-05-31

1994-06-21

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 435 76, 435822, 536 221, 536 231, 536 232, C12P 2106, C12P 1962, A01N 3718, C07H 1900

Patent

active

053229371

ABSTRACT:
A DNA fragment or a restriction enzyme-digested DNA fragment, the DNA fragment containing a gene, acyA, encoding a 3-acylation enzyme for macrolide antibiotics, characterized by being derived from a strain belonging to the genus Streptomyces, having a size of about 1.8 kb or about 3.2 kb, and having a DNA base sequence shown in a restriction enzyme map shown in FIG. 1(A) or FIG. 1(B), respectively, in the attached drawing. 3-Acylated macrolide antibiotics can be produced advantageously using macrolide antibiotics-producing bacteria transformed with vector plasmids having inserted therein the DNA fragment.

REFERENCES:
patent: 4201843 (1980-05-01), Okamoto et al.
Epp et al., "Production of a hybrid macrolide antibiotic . . . ", Gene, vol. 85, 1989, pp. 293-301.
Tashiro et al., Zoku Seikgaku Jikken Koza (Second Series: Course of Biochemical Experiments), vol. 1, Zdenshi Kenkyuso (Methods of Gene Study) II, 83-104 (1986), ed. by Japan Biochemistry Society.

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