Genes differentially expressed in breast cancer

Details Genes differentially expressed in breast cancer Genes differentially expressed in breast cancer

2001-01-09

2009-10-20

Harris, Alana M (Department: 1643)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S018700, C536S022100, C536S023100, C435S069100, C530S350000, C436S064000, C436S086000

Reexamination Certificate

active

07605246

ABSTRACT:
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.

REFERENCES:
patent: 2002/0081659 (2002-06-01), Rosen et al.
patent: WO 93/16180 (1993-08-01), None
patent: WO 00/55320 (2000-09-01), None
GenCore database sheets (3 sheets) Sequence alignment between US Patent Application Publication No. 2002/0081659 A1 sequence 71 versus Applicants' SEQ ID No. 1 (nucleic acid) and SEQ ID No. 2 (amino acid).
Boehringer Mannheim Biochemicals 1991 Catalog, p. 557.
Lazar et al. Transforming Growth Factor alpha: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities 8(3): 1247, Mar. 1988.
Thompson et al, “Association of Increased Basement Membrane Invasiveness With Abesence of Estrogen Receptor and Expression of Vimentin in Human Breast Cancer Cell Lines,”J. Cell Physiol. 150(3):534-544, Mar. 1992.
Tomlinson et al., “Loss of Heterozygosity on Chromosome 11q in Breast Cancer,”J. Clin. Pathol. 48(5):424-428, May 1995.
Winqvist et al., “Loss of Heterozygosity for Chromosome 11 in Primary Human Breast Tumors Is Associated with Poor Survival after Metastasis,”Cancer Res. 55(12):2660-2664. Jun. 15, 1995.
Anisowicz et al., “A Novel Protease Homolog Differentially Expressed in Breast and Ovarian Cancer,”Molecular Medicine2(5):624-636, Sep. 1, 1996.
Database EMBL, Accession No. AC018997, Dec. 26, 1999.
Albini et al., “A Rapid in Vitro Assay for Quantitating the Invasive Potential of Tumor Cells,”Cancer Res. 47(12):3239-3245, Jun. 15, 1987.
Bergstrom et al., “Regulatory Autonomy and Molecular Characterization of the Drosophilaout at first Gene,”Genetics139(3):1331-1346, Mar. 1995.
Engel et al., “Establishment and Characterization of Three New Continuous Cell Lines Derived from Human Breast Carcinomas,”Cancer Res. 38(10):3352-3364, Oct. 1978.
Kramer et al., “Invasion of Reconstituted Basement Membrane Matrix by Metastatic Human Tumor Cells”Cancer Res. 46(4 Part 2):1980-89, Apr. 1986.
Merli et al., “Promoter Specificity Mediates the Independent Regulation of Neighboring Genes,”Genes Dev. 10(10):1260-1270, May 15, 1996.
Negrini et al., “Definition and Refinement of Chromosome 11 Regions of Loss of Heterozygosity in Breast Cancer: Identification of a New Region at 11q23.3,”Cancer Res.55(14):3003-3007, Jul. 15, 1995.
Rishi et al., “Regulation of theHuman Retinoic Acid Receptor αGene in the Estrogen Receptor Negative Human Breast Carcinoma Cell Lines SKBR-3 and MDA-MB-435,”Cancer Res. 56(22):5246-5252, Nov. 15, 1996.
Sugiura et al. “Function of α3β1-Tetraspanin Protein Complexes in Tumor Cell Invasion. Evidence for the Role of the Complexes in Production of Matrix Metalloproteinase 2 (MMP-2),”J. Cell Biol. 146(6):1375-1389, Sep. 20, 1999.

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