Genes differentially expressed in breast cancer

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S300000, C530S350000, C530S385000, C530S386000, C530S387700

Reexamination Certificate

active

07081517

ABSTRACT:
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.

REFERENCES:
patent: 2002/0081659 (2002-06-01), Rosen et al.
patent: 2004/0081659 (2004-04-01), Brady et al.
patent: WO 93/16180 (1993-08-01), None
patent: WO 00/55320 (2000-09-01), None
Colman, P.M. Effects of amino acid sequence changes on antibody-antigen interactions. Research in Immunology 145:33-36, 1994.
Lazar et al. Transforming Growth Factor alpha: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities. Molecular and Cellular Biology 8(3): 1247-1252, Mar. 1988.
Accession No. AC018997, Dec. 26, 1999.
Albini et al., “A Rapid in Vitro Assay for Quantitating the Invasive Potential of Tumor Cells,” Cancer Res. 47(12):3239-3245, Jun. 15, 1987.
Anisowicz et al., “A Novel Protease Homolog Differentially Expressed in Breast and Ovarian Cancer,” Molecular Medicine 2(5):624-636, Sep. 1, 1996.
Bergstrom et al., “Regulatory Autonomy and Molecular Characterization of theDrosophilaout at first Gene,” Genetics 139(3):1331-1346, Mar. 1995.
Colman, P.M., “Effects of amino acid sequence changes on antibody-antigen interactions,”Research in Immunology145:33-36, 1994.
Engel et al., “Establishment and Characterization of Three New Continuous Cell Lines Derived from Human Breast Carcinomas,” Cancer Res. 38(10):3352-3364, Oct. 1978.□
Kramer et al., “Invasion of Reconstituted Basement Membrane Matrix by Metastatic Human Tumor Cells” Cancer Res. 46(4 Part 2):1980-89, Apr. 1986.
Lazar et al., n“Transforming Growth Factor Alpha: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities,”Molecular and Cellular Biology8(3):1247-1252, Mar. 1988.
Merli et al., “Promoter Specificity Mediates the Independent Regulation of Neighboring Genes,” Genes Dev. 10(10):1260-1270, May 15, 1996.
Negrini et al., “Definition and Refinement of Chromosome 11 Regions of Loss of Heterozygosity in Breast Cancer: Identification of a New Region at 11q23.3,” Cancer Res.55(14):3003-3007, Jul. 15, 1995.
Rishi et al., “Regulation of the Human Retinoic Acid Receptor αGene in the Estrogen Receptor Negative Human Breast Carcinoma Cell Lines SKBR-3 and MDA-MB-435,”Cancer Res. 56(22):5246-5252, Nov. 15, 1996.
Sugiura et al. “Function of α3β1-Tetraspanin Protein Complexes in Tumor Cell Invasion. Evidence for the Role of the Complexes in Production of Matrix Metalloproteinase 2 (MMP-2),” J. Cell Biol. 146(6):1375-1389, Sep. 20, 1999.
Thompson et al, “Association of Increased Basement Membrane Invasiveness With Abesence of Estrogen Receptor and Expression of Vimentin in Human Breast Cancer Cell Lines,” J. Cell Physiol. 150(3):534-544, Mar. 1992.
Tomlinson et al., “Loss of Heterozygosity on Chromosome 11q in Breast Cancer,” J. Clin. Pathol. 48(5):424-428, May 1995.
Winqvist et al., “Loss of Heterozygosity for Chromosome 11 in Primary Human Breast Tumors Is Associated with Poor Survival after Metastasis,” Cancer Res. 55(12):2660-2664. Jun. 15,1995.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Genes differentially expressed in breast cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genes differentially expressed in breast cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes differentially expressed in breast cancer will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3592387

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.