Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-10-09
2007-10-09
Prouty, Rebecca E. (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S006120, C435S325000, C435S069100, C435S320100, C514S012200, C536S023500, C536S023200
Reexamination Certificate
active
11051410
ABSTRACT:
A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
REFERENCES:
Aoki, et al. (1999). Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Potential role of p53 in regulation of vascular smooth muscle cell growth. Hypertension. 34(2):192-200.
Bednarek, et al. (2000). WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res. 60(8):2140-2145.
Bednarek, et al. (2001). WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res. 61(22):8068-8073.
Chang, et al. (2001). Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem. 276(5):3361-3370.
Gmerek, et al. Database Genbank Accession No. U13395. National Library of Medicine, Bethesda, MD, Sep. 15, 1994.
International Preliminary Examination Report dated Dec. 10, 2001.
Maskos, et al. (1998). Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme. Proc Natl Acad Sci USA. 95(7):3408-3412.
Nishida, et al. (1997). Analysis of gene expression control mechanism in smooth muscle cell transformation (differentiation and dedifferentiation). Cell Technology. 16(10):1496-1508.
Paige, et al. (2001). WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci USA. 98(20):11417-11422.
Yackicier , et al. (2001). Identification of homozygous deletions at chromosome 16q23 in aflatoxin B1 exposed hepatocellular carcinoma. Oncogene. 20(37):5232-5238.
Funahashi Shin-Ichi
Hayashi Ken'ichiro
Hayashi Koji
Ishii Shizuko
Isogai Takao
Chugai Seiyaku Kabushiki Kaisha
Fish & Richardson P.C.
Sobue Kenji
LandOfFree
Genes associated with the maintenance of differentiation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genes associated with the maintenance of differentiation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes associated with the maintenance of differentiation of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3898938