Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-06-21
2005-06-21
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
Reexamination Certificate
active
06908748
ABSTRACT:
A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.
REFERENCES:
Gmerek et al. Database Genbank Accession No. U13395. National Library of Medicine, Bethesda, MD, Sep. 15, 1994.
Bednarek, et al., “WWOX, a Novel WW Domain-containing Protein Mapping to Human Chromosome 16q23.3-24.1, a Region Frequently affected in Breast Cancer”;Cancer Research, vol. 60, pp 2140-2145 (2000).
Bednarek, et al., “WWOX, the FRA16D Gene, Behaves as a Suppressor of Tumor Growth”,Cancer Research, vol. 61, pp 8068-8073 (2001).
Chang, et al., “Hyaluronidase Induction of a WW Domain-containing Oxidoreductase That Enhances Tumor Necrosis Factor Cytotoxicity”,The Journal of Biological Chemistry, vol. 276, No. 5, pp. 3361-3370, (2001).
Paige, et al., “WWOX: A candidate tumor suppressor gene involved in multiple tumor types”,PNAS, vol. 98, No. 20, pp. 11417-11422 (2001).
Yakicier, et al., “Identification of homozygous deletions at chromosome 16q23 in Aflotoxin B1 exposed hepatocellular carcinoma”,Oncogene, vol. 20, pp 5232-5238 (2001).
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International Preliminary Examination Report dated Oct. 12, 2001 (Translation of Ref. AQ) (3 pages).
Funahashi Shin-Ichi
Hayashi Ken'ichiro
Hayashi Koji
Ishii Shizuko
Isogai Takao
Carlson Karen Cochrane
Chugai Seiyaku Kabushiki Kaisha
Fish & Richardson P.C.
Snedden Sheridan K
Sobue Kenji
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