Genes and proteins controlling cholesterol synthesis

Details Genes and proteins controlling cholesterol synthesis Genes and proteins controlling cholesterol synthesis

1996-08-16

2000-08-22

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

536 235, 536 237, 435 691, C07K 100, C07H 2104, C12P 2106

Patent

active

061074624

ABSTRACT:
The present invention provides isolated nucleic acid sequences which encode a family of HMG-CoA Reductase Degradation (HRD) polypeptides. More particularly, the present invention provides isolated HRD1, HRD2 and HRD3 nucleic acids and the Hrd polypeptides encoded by such nucleic acids, i.e., Hrd1, Hrd2 and Hrd3, respectively. Vectors comprising the nucleic acids are provided. In addition, the present invention provides screening assay related to cholesterol biosynthesis.

REFERENCES:
patent: 5356896 (1994-10-01), Kabadi et al.
patent: 5491164 (1996-02-01), deSolms et al.
patent: 5523456 (1996-06-01), Stokker et al.
patent: 5532359 (1996-07-01), Marsters, Jr. et al.
Ashby and Rine, 1995, Methods in Enzymology, 250:235-250.
Basson et al., 1988, Mol. Cell Biol., 8:3797-3808.
Boeke et al., 1987, Methods Enzymol, 154:164-175.
Chen et al., 1995, Embo Journal, 14(11):2620-2630.
DeMarini et al., 1995, Mol. Cell Biol., 15:6311-6321.
DeMartino et al., 1994, J. Biol. Chem, 269:20878-20884.
Egner and Kuchler, 1996, Febs Lett, 378:177-181.
Evan et al., 1985, Mol. Cell Biol., 5:3610-3616.
Freemont, 1993, Ann NY Acad Sci, 684:174-192.
Gietz and Sugino, 1988, Gene, 74:527-534.
Goldberg, 1995, Science, 268(5210):522-523.
Grant and Greenwald, 1996, Genetics, 143:237-247.
Hampton et al., 1996, "Role of 26S Proteasome and HRD Genes in the Degradation of 3-Hydroxy-3-Methylglutaryl-CoA Reductase, an Integral Endoplasmic Reticulum Membrane Protein," Molecular Biology of the Cell 7:2029-2044.
Hampton et al., 1996, Proc. Natl. Acad. Sci. USA, 93:828-833.
Hampton and Rine, 1994, J. Cell Biol., 125:299-312.
Heilmeyer, Jr. et al., Oct. 1992, Proc. Natl. Acad. Sci. USA, 89:9554-9558.
Hicke and Riezman, 1996, Cell, 84:277-287.
Higgins and Sharp, 1989, CABIOS, 5:151-153.
Higgins and Sharp, 1988, Gene, 73:237-244.
Hilt and Wolf, 1995, Mol Biol Rep, 21:3-10.
Hrycyna, et al., 1991, EMBO Journal, 10(7):1699-1709.
Inoue et al., 1991, J. Biol Chem, 266:13311-13317.
Jensen et al., 1995, Cell, 83:129-135.
Kato et al., Jul. 1992, Proc. Natl. Acad. Sci. USA, 89:6403-6407.
Lecureux and Wattenberg, 1994, J. Cell Science, 107:2635-2642.
Lorenz et al., 1995, Gene, 158:113-117.
McCracken and Brodsky, 1996, J Cell Biol, 132:291-298.
Meyers and Miller, 1988, Computer Applic. Biol. Sci., 4:11-17.
Papa and Hochstrasser, 1993, Nature, 366:313-319.
Rechsteiner et al., 1993, Journal of Biological Chemistry, 268(9):6065-6068.
Rose et al., 1987, Gene, 60:237-243.
Sipos and von Heijne, 1993, Eur. J. Biochem, 213:1333-1340.
Song et al., 1995, J. Biol. Chem., 270:3574-3581.
Tanaka et al., 1992, New Biologist, 4(3):173-187.
Tierney et al., 1992, Arch Biochem Biophys, 293:9-16.
Ward et al., 1995, Cell, 83:121-127.
Weirtz et al., 1996, Cell, 84:769-779.
Johnston et al., Science 265:2077-2082, 1994.

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