Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2004-08-10
2008-09-16
Helms, Larry (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S300000
Reexamination Certificate
active
07425612
ABSTRACT:
The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
REFERENCES:
patent: 2003/0228584 (2003-12-01), Tang et al.
patent: 1 321 475 (2003-06-01), None
patent: WO 00/50588 (2000-08-01), None
patent: WO 01/22920 (2001-04-01), None
patent: WO 01/54472 (2001-08-01), None
patent: WO 01/55202 (2001-08-01), None
patent: WO 01/66689 (2001-09-01), None
patent: WO 01/66689 (2001-09-01), None
patent: WO 01/66689 (2001-09-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO 01/75067 (2001-10-01), None
Lee et al (J. Immunol., 1999, 163:6292-6300).
Kirkin et al (1998, APMIS, 106 : 665-679).
Chaux et al, (Int J Cancer, 1998, 77: 538-542).
Boon (Adv Can Res, 1992, 58:177-210).
Celis (J of Clinical Investigation, 2002, 110:1765-1768).
Bowie et al (Science, 1990, 247:1306-1310).
Kawakami, T., et al.; Database; UniProt; Accession No. Q9NXDO; Oct. 10, 2001.
Nagase, Takahiro, et al.; “Prediction of the Coding Sequences of Unidentified Human Genes. V. The Coding Sequences of 40 New Genes (KIAA0161-KIAA0200) Deduced by Analysis of cDNA Clones From Human Cell Line KG-1”;DNA Research Institute; Feb. 29, 1996; pp. 17-24; vol. 3, No. 1.
Perrais, Michaël et al.; “Aberrant expression of human mucin geneMUC5Bin gastric carcinoma and cancer cells: Identification and regulation of a distal promoter”;The Journal of Biological Chemistry; May 4, 2001; pp. 15386-15396; vol. 376, No. 18; The American Society for Biochemistry and Molecular Biology, Inc; USA.
Alexander-Miller, Martha A. et al.; “Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy”;Proc. Natl. Acad. Sci. USA93:4102-7107; Apr. 1996.
Altieri, Dario C. and Carlo Marchisio; “SurvivinApoptosis: An Interloper Between Cell Death and Cell Proliferation in Cancer”;Laboratory Investigation79(11):1327-1333; Nov. 1999.
Anderson, Mads Hald et al.; “Identification of a Cytotoxic T Lymphocyte Response to the Apoptosis Inhibitor Protein Survivin in Cancer Patients”;Cancer Research61:869-872; Feb. 1, 2000.
Artavanis-Tsakonas, Spyros et al.; “TheNotchLocus and the Cell Biology of Neuroblast Segregation”;Annu. Rev. Cell Biol.7:427-452; 1991; Annual Reviews Inc.
Bednarek, Maria A. et al.; “The minimum peptide epitope from the influenza virus matrix protein: Extra and intracellular loading of HLA-A2”The Journal of Immunology147(12):4047-4053; Dec. 15, 1991.
Bienz, Mariann and Hans Clevers; “Linking Colorectal Cancer to Wnt Signaling”;Cell103:311-320; Oct. 13, 2000; Cell Press.
Boon, Thierry; “Tumor Antigens Recognized by Cytolytic T lymphocytes: Present Perspectives for Specific Immunotherapy”;Int. J. Cancer54:177-180; 1993; Wily-Liss, Inc.
Boon, Thierry and Pierre van der Bruggen; “Human Tumor Antigens Recognized by T Lymphocytes”;J. Exp. Med.183:725-729; Mar. 1996.
Brichard, Vincent et al.; “The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas”;J. Exp. Med.178:489-495; Aug. 1993.
Butterfield, Lisa H. et al.; “Generation of Human T-cell Responses to an HLA-A2. 1-resticted Peptide Epitope Derived from α-Fetoprotein”;Cancer Research59:3134-3142; Jul. 1, 1999.
Chen, Yao-Tseng et al.; “A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening”;Proc. Natl. Acad. Sci. U.S.A.94:1914-1918; Mar. 1997.
Clay, Timothy M. et al.; “Changes in the Fine Specificity of gp100(209-217)-Reactive T Cells in Patients Following Vaccination with a Peptide Modified at an HLA-A2. 1 Anchor Residue”;The Journal of Immunology162;1749-1755; 1999.
Date, Y. et al.; “DNA typing of the HLA-A gene: population study and identification of four new alleles in Japanese”;Tissue Antigens47:93-101; 1996.
Dionne, Sara O. et al.; “Functional characterization of CTL against gp100 altered peptide ligands”;Cancer Immunol Immunother52:199-206; 2003.
Dionne, Sara O. et al.; “Her-2
eualtered peptide ligand-induced CTL responses: implications for peptides with increased HLA affinity and T-cell-receptor interaction”;Cancer Immunol Immunother53:307-314; 2004.
Dyall, Ruben et al.; “Heteroclitic Immunization Induces Tumor Immunity”;J. Exp. Med.188(9):1553-1561; Nov. 2, 1998; The Rockefeller University Press.
Fechner, H. et al.; “Expression of Coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers”;Gene Therapy6:1520-1535; 1999; Stockton Press.
Fujie, Tatsuo et al.; “AMAGE-1-encoded HLA-A24-binding synthetic peptide induces specific anti-tumor cytotoxic T lymphocytes”;Int. J. Cancer80:169-172; 1999; Wiley Liss, Inc.
Fujita, Manabu et al.; “Up-Regulation of the Ectodermal-Neural Cortex 1 (ENC1) Gene, a Downstream Target of the β-Catenin/T-Cell Factor Complex, in Colorectal Carcinomas”;Cancer Research61:7722-7726; Nov. 1, 2001.
Harris, Curtis C.; “Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies”;Journal of the National Cancer Institute88(20):1442-1455; Oct. 16, 1996.
Hasegawa, Suguru et al.; “Genome-Wide Analysis of Gene Expression in Intestinal-Type Gastric Cancers Using a Complementary DNA Microarray Representing 23,040 Genes”;Cancer Research62:7012-7017; Dec. 1, 2002.
He, Tong-Chuan et al.; “PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-inflammatory Drugs”;Cell99:335-345; Oct. 29, 1999; Cell Press.
Hu, Xueyou et al.; “Enhancement of Cytolytic T Lymphocyte Precursor Frequency in Melanoma Patients Following Immunization with the MAGE-1 Peptide Loaded Antigen Presenting Cell-based Vaccine”;Cancer Research56:2479-2483; Jun. 1, 1996.
Imanishi, Tadashi et al.; “Allele and haplotype frequencies for HLA and complement loci in various ethnic groups”;Proceedings of the Eleventh International Histocompatibility Workshop and Conference; pp. 1065-1220; 1992; Oxford University Press.
Irvine, Kari R. et al.; “Recombinant virus vaccination against “self” antigens using anchor-fixed immunogens”;Cancer Research59:2536-2540; Jun. 1, 19999.
Kawakami, Yutaka et al.; “Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes”;The Journal of Experimental Medicine180:347-352; Jul. 1994.
Kawano, Kouichiro et al.; “Identification of a new endoplasmic reticulum-resident protein recognized by HLA-A24-restricted tumor-infiltrating lymphocytes of lung cancer”;Cancer Research60:3550-3558; Jul. 1, 2000.
Keogh, Elissa et al.; “Identification of new epitopes from four different tumor-associated antigens: Recognition of naturally processed epitopes correlates with HLA-A*0201-binding affinity”;The Journal of Immunology167:787-796; 2001.
Kikuchi, Megumi et al.; “Identification of a SART-1-derived peptide capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes”;Int. J. Cancer81:459-466; 1999.
Kitahara, Osamu et al.; “Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia”;Cancer Research61:3544-3549; May 1, 2001.
Kondo, Akihiro et al.; “Prominent roles of secondary anchor residues in peptide binding to HLA-A24 human class I molecules”;The Jo
Furukawa Yoichi
Nakamura Yusuke
Tahara Hideaki
Tsunoda Takuya
Goddard Laura B
Helms Larry
Oncotherapy Science, Inc.
Townsend and Townsend / and Crew LLP
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