Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2005-03-01
2005-03-01
Monshipouri, Maryam (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S006120, C435S325000, C435S320100, C435S252300, C536S023200
Reexamination Certificate
active
06861239
ABSTRACT:
The invention relates to novel polynucleotides and their encoded gene products that are expressed in skin cells, particularly keratinocytes, and methods of using the same. Specifically, the present invention provides polynucleotides encoding several novel protein kinases that are c-Jun N-terminal kinase kinase kinases, i.e., MLK4, PAK4, PAK5 and YSK2. In addition, the invention provides methods of using the disclosed polynucleotides and their gene products in drug discovery, particularly in screening for drugs that can reduce ultraviolet light-induced damage of the skin, inflammation and psoriasis, and drugs that can enhance wound healing.
REFERENCES:
patent: 5854043 (1998-12-01), Johnson
patent: 2 369 172 (1999-10-01), None
Diener et al., “Activation of the c-Jun N-terminal Kinase Pathway by a Novel Protein Kinase Related to Human Germinal Center Kinase,” Proc. Natl. Acad. Sci., USA, vol. 94, 1997, pp 9687-9692.
Tibbles et al., “The Stress-Activated Protein Kinase Pathways,” Cellular and Molecular Life Sciences, vol. 55, 1999, pp 1230-1254.
Latkowski et al., “Epidermal Cell Kinetics, Epidermal Differentiation, and Keratinization,” Fitzpatrick's Dermatology in Medicine (book) 1999 McGraw Hill pp 133-144.
Herrlich et al., “The Mammalian UV Response: Mechanism of DNA Damage Induced Gene Expression,” Advan. Enzyme Regul. vol. 34, 1995, 381-395.
Ullrich et al., “The Role of Cytokines in UV-Induced Systemic Immune Suppression,” Journal of Dermatological Science, vol. 23, 2000 Abstract, 510-512.
Ouhtit et al., “Temporal Events in Skin Injury and the Early Adaptive Responses in Ultraviolet-Irradiated Mouse Skin,” American Journal of Pathology, vol. 156, No. 1, Jan. 2000, pp 201-207.
Beissert et al., “Mechanisms Involved in Ultraviolet Light-Induced Immunosuppression,” J. Investig. Dermatol. Symp. Proc., vol. 4, No. 1, pp 61-63.
Barnes et al., “Mechanisms of Disease,” The New England Journal of Medicine, vol. 336, No. 15, Apr. 10, 1997, pp 1066-1071.
Osada et al., “YSK1, a novel mammalian protein kinase structurally related to Ste 20 and SPS1, but is not involved in the known MAPK pathways” Oncogene vol. 14, 1997, pp 2047-2057.
Dorow et al., “Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains,”Eur. J. Biochem., vol. 213, No. 2, 1993, 701-710.
Su et al., “Signal transduction by the JNK MAPK cascade and ultraviolet light induced cytokine gene expression,”Photochemistry and Photobiology, vol. 67, Special Issue, 1998, 60S.
Abo et al., “PAK4, a Novel Effector for Cdc42Ha, is Implicated in the Reorganization of the Actin Cytoskeleton and in the Formation of Filopodia,” EMBO Journal, vol. 17, pp 6527-6540, 1998.
Broun et al., “Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids,” Science, vol. 282, Nov. 13, 1998, pp 1315-1317.
Ng et al., “Point Mutation in the Second Phosphatase Domain of CD45 Abrogates Tyrosine Phosphatase Activity,” Biochemcial and Biophysical Research Communications, vol. 206, No. 1, Jan. 5, 1995, pp 302-309.
Blumenberg Miroslav
Gazel Alix M.
Monshipouri Maryam
New York University
Wilmer Cutler Pickering Hale and Dorr LLP
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