Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-03-02
1998-05-19
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435 9141, 4351723, C12Q 168, C12P 2102, C12N 1564, C12N 1512
Patent
active
057534322
ABSTRACT:
The invention provides genetic suppressor elements that confer the transformed phenotype of malignant mammalian cells upon untransformed cells, methods for identifying and obtaining such elements, methods for isolating and identifying genes corresponding to such elements, and methods of using such elements. The invention also provides genes corresponding to the GSEs of the invention.
REFERENCES:
patent: 5217889 (1993-06-01), Roninson
Graf & Beug, 1983, "Role of the v-erbA and v-erbB Oncogenes of Avian Erythroblastosis Virus in Erythroid Cell Transformation", Cell 34:7-9.
Eliyahu et al., 1984, "Participation of p53 cellular tumour antigen in transformation of normal embryonic cells", Nature 312:646-649.
Parada et al., 1984, "Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation", Nature 312:649-651.
Lau and Nathans, 1985, "Identification of a set of genes expressed during the Go/G1 transition of cultured mouse cells", EMBO J. 4: 3145-3151.
Chen et al., 1986, "Internal Duplication and Homology with Bacterial Transport Proteins in the mdr1 (P-Glycoprotein) Gene from Multidrug-Resistant Human Cells", Cell 47: 381-389.
Sap et al., 1986, "The c-erb-A protein is a high-affinity receptor for thyroid hormone", Nature 324: 635-640.
Weinberger et al., 1986, "The c-erb-A gene encodes a thyroid hormone receptor", Nature 324:641-646.
Herskowitz, 1987, "Functional inactivation of genes by dominant negative mutations", Nature 329:219-222.
Damm et al., 1987, "A single point mutation in erbA restores the erythroid transforming potential of a mutant avian erythroblastosis virus (AEV) defective in both erbA and erbB oncogenes", EMBO J. 6:375-382.
Kinzler et al., 1987, "Identification of an Amplified, Highly Expressed Gene in a Human Carcinoma", Science 236:70-73.
Lee et al., 1987, "The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity", Nature 329:642-645.
Friend et al., 1987, "Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein", Proc. Natl. Acad. Sci. USA 84:9059-9063.
Barbacid, 1987, "ras Genes", Ann. Rev. Biochem. 56:779-827.
Lau and Nathans, 1987, "Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc", Proc. Natl. Acad. Sci. USA 84: 1182-1186.
Vale, 1987, "Intracellular transport using microtubule-based motors", Ann. Rev. Cell Biol. 3: 347-378.
Bender et al., 1987, "Evidence that the Packaging Signal of Moloney Murine Leukemia Virus Extends into the gag Region", J. Virol. 61: 1639-1646.
Markowitz et al., 1988, "Construction and Use of a Safe and Efficient Amphotropic Packaging Cell Line", Virology 167: 400-406.
Pauwels et al., 1988, "Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds", J. Virol. Meth. 20: 309-321.
Finlay et al., 1988, "Activating Mutations for Transformation by p53 Produce a gene Product that Forms an hsc70-p53 Complex with an Altered Half-Life", Molec. Cell. Biol. 8: 531-539.
Vogelstein et al., 1988, "Genetic Alterations during Colorectal-Tumor Development", N. Engl. J. Med. 319: 525-532.
Schwab et al., 1989, "Amplified DNA in cells of genetic melanoma of Xiphophorus", Oncogene 4: 139-144.
Trent et al., 1989, "Identification of a Recurring Translocation Site Involving Chromosome 6 in Human Malignant Melanoma", Cancer Res. 49: 420-423.
Damm et al., 1989, "Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist", Nature 339: 593-597.
Montenarh & Quaiser, 1989, "Two different protein-protein interactions in oligomeric complexes of SV40 large T antigen with the cellular oncoprotein p53", Oncogene 4: 379-382.
Sap et al., 1989, "Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene", Nature 340: 242-244.
Varmus, 1989, "A historical overview of oncogenes", in Oncogenes and the Molecular Origin of Cancer, Weinberg, ed., Cold Spring Harbor Press, Cold Spring Harbor, N.Y., pp. 3-44.
Ohara et al., 1989, "One-sided polymerase chain reaction: the amplification of cDNA", Proc. Natl. Acad. Sci. USA 86: 5673-5677.
Albritton et al., 1989, "A Putative Murine Ecotropic Retrovirus Receptor Gene Encodes a Multiple Membrane-Spanning Protein and Confers Susceptibility to Virus Infection", Cell 57: 659-666.
Miller and Rosman, 1989, "Improved Retroviral Vectors for Gene transfer and Expression", Biotechniques 7: 980-986.
McConkey et al., 1989, "Glucocorticoids Activate a Suicide Process in Thymocytes through an Elevation of Cytosolic Ca.sup.2+ Concentration", Arch. Biochem. Biophys. 269: 365-370.
Altshul et al., 1990, "Basic Local Alignment Search Tool", J. Mol. Biol. 215: 403-410.
Noonan et al., 1990, "Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction", Proc. Natl. Acad. Sci. USA 87: 7160-7164.
Kung et al., 1990, "Cytotosic Effects of Cell Cycle Phase Specific Agents: Result of Cell Cycle Perturbation", Cancer Res. 50: 7307-7317.
Uhlmann and Peyman, 1990, "Antisense Oligonucleotides: A New Therapeutic Principle", Chemical Reviews 90: 543-584.
Schneider and Banner, 1990, "Building blocks for oligonucleotide analogs with dimethylene-sulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages", Tetrahedron Letters 31: 335.
Bodine et al., 1990, "Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells", Proc. Natl. Acad. Sci. USA 87: 3738-3742.
Fearon et al., 1990, "Identification of a Chromosome 18q Gene that is Altered in Colorectal Cancers", Science 247: 49-56.
Xu et al., 1990, "The Neurofibromatosis Type 1 Gene Encodes a Protein Related to GAP", Cell 62: 599-608.
Ballester et al., 1990, "The NF1 Locus Encodes a Protein Functionally Related to Mammalian GAP and Yeast IRA Proteins", Cell 62: 851-859.
Buchberg et al., 1990, "Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway", Nature 347: 291-294.
Fields et al., 1990, "Presence of a Potent Transcription Activating Sequence in the p53 Protein", Science 249: 1046-1049.
O'Rourke et al., 1990, "A potential transcriptional activation element in the p53 protein", Oncogene 5: 1829-1832.
Raycroft et al., 1990, "Transcriptional Activation by Wild-Type but not Transforming Mutants of the p53 anti-Oncogene", Science 249: 1049-1051.
Nakatani et al., 1990, "Isolation of an Amplified DNA Sequence in Stomach Cancer", Jpn. J. Cancer Res. 81: 707-710.
Call et al., 1990, "Isolation and Characterization of a Zinc Finger Polypeptide Gene at the Human Chromosome 11 Wilms' Tumor Locus ", Cell 60: 509-520.
Gessler et al., 1990, "Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping", Nature 343: 774-778.
Viskochil et al., 1990, "Deletions and a Translocation Interrupt a Cloned Gene at the Neurofibromatosis Type-1 Locus", Cell 62: 187-192.
Milner et al., 1991, "Tumor Suppressor p53: Analysis of Wild-Type and Mutant p53 Complexes", Molec. Cell. Biol. 11: 12-19.
Friend et al., 1991, "Identification of a Gene Located at Chromosome 5q21 that is Mutated in Colorectal Cancers", Science 251: 1366-1370.
Hunter, 1991, "Cooperation between Oncogenes", Cell 64: 249-270.
Weinberg, 1991, "Tumor Suppressor Genes", Science 254: 1138-1146.
Kern et al., 1991, "Mutant p53 proteins bind DNA abnormally in vitro", Oncogene 6: 131-136.
Kern et al., 1991, "Identification of p53 as a Sequence-Specific DNA Binding Protein", Science 252: 1708-1711.
Solomon et al., 1991, "Chromosome Aberrations and Cancer", Science 254: 1153-1160.
LaForgia et al., 1991, "Receptor protein-tyrosine phosphatase .gamma. is a candidate tumor suppressor gene at human chromosome region 3p21", Proc. Natl. Acad. Sci. USA 88: 5036-5040.
Baim et al., 1991, "A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl .beta.-D-thiogalactopyranoside", Proc. Natl. Acad. Sci. USA 88: 507
Gudkov Andrei
Kazarov Alexander
Mazo Ilya
Roninson Igor B.
Board of Trustees of the University of Illinois
Brusca John S.
Ketter James
LandOfFree
Genes and genetic elements associated with control of neoplastic does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genes and genetic elements associated with control of neoplastic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes and genetic elements associated with control of neoplastic will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1851720