Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1994-04-22
1995-09-12
Niebling, John
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
C07K 100
Patent
active
054497540
ABSTRACT:
Ink-jet printing technology is applied to the creation of multi unit chemical compound libraries. Ink-jet type nozzles are used to inject multiple droplets onto the surface an appropriate support, such droplets consisting of solutions containing units of the chemical compound that will attach to the support surface. Droplets are then injected, by such nozzles, onto the support attached unit droplets that contain units that will attach to such support attached units. The second step is repeated to create multiple varying unit chemical compounds. Ink-jet printing technology allows the deposition of small droplets that do not overlap or splatter. The system is particularly useful in the creation of libraries of multiple peptide compounds where the units are amino acids.
REFERENCES:
patent: 4704583 (1987-11-01), Gould
patent: 4746201 (1988-05-01), Gould
patent: 4816513 (1989-03-01), Bridgham et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5258454 (1993-11-01), Berg et al.
patent: 5288514 (1994-02-01), Ellman
Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide, by R. B. Merrifield, "Merrifield" J. Am. Chem. Soc. (1963) 85:2149-2154, QUI Am 35j.
"Single--Domain Antibodies Promise New Chemical, Medical Applications" C&E News, Nov. 20, 1989.
"Lights! Camera! Print It! Laser Printer Technology Explained" Alfred Poor (PC Magazine, Nov. 14, 1989, pp. 168-169.)
"Light-Directed, Spatially Addressable Parallel Chemical Snythesis" S. Fodor, et al., Science, 251, 767 (1991).
"Photoremovable Protecting Groups in Organic Synthesis" V. N. Pullai, Synthesis, 1 (1980).
A. Patchornik, et al., JACS, 92, 6333 (1970) Photosensitive Protecting Groups.
"Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli" E. S. Ward, et al., Nature, vol. 341, 544 (1989).
"Peptides, Structure and Function" edited by C. M. Deber, V. J. Hruby, and K. D. Kopple, Pierce Chemical Co., Rockford, Ill., (1985).
"Searching for Peptide Ligands with an Epitope Library" J. K. Scott and G. P. Smith, Science, vol. 249, 386 (1990).
"Random Peptide Libraries: A Source of Specific Protein Binding Molecules" J. J. Devlin, L. C. Panganiban, and P. E. Devlin, Science, vol. 249, 404 (1990).
"Laser Recording And Image-Quality Evaluation" K. Minoura, et al., SPIE, vol. 1254, 24 (1990).
"A laser scanning optical system for high-resolution laser printer" T. Maruyama, et al., SPIE, vol. 1254, 54 (1990).
"Immunogenicity of Synthetic Peptides Corresponding to Flexible and Antibody-accessible Segments of Mouse Lactate Dehydrogenase (LDH)-C.sub.4 *"H. Hogrefe, P. Kaumaya, and E. Goldberg, J. Biol. Chem., vol. 264, 10513 (1989).
"Peptide engineering of protein topographic determinants for vaccines" P. Kaumaya, et al., in "Peptides 1990", ESCOM Science B.V. (1991).
"Synthesis and Biophysical Characterization of Engineered Topographic Immunogenic Determinants with aa Topology" P. Kaumaya et al., Biochemistry, 29, 13 (1990).
Internet memorandum: David B. Wallace, "Fluid Microdispensing In Genosensor Development", Oct. 29-30, 1993, one page.
Delacroix-Muirheid C.
H & N Instruments, Inc.
Millard Sidney W.
Niebling John
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