Generation of cartilage using magnetizable particles

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...

Reexamination Certificate

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C424S646000, C428S842200, C600S009000, C600S012000, C600S014000, C977S904000, C977S906000

Reexamination Certificate

active

07625562

ABSTRACT:
There is described a method of magnetically manipulating a cell in vivo which comprises the association of a magnetizable particle with a cell. More particularly, there is described a method of magnetically manipulating a cell which comprises the association of a magnetizable particle with a cell characterized in that the method comprises agonizing or antagonizing ion channels within a cell by the association of a magnetizable particle with a cell. There is also described the use of a magnetizable particle in a method of magnetically manipulating a cell in vivo and/or activating ion channels in vivo.

REFERENCES:
patent: 2004/0147015 (2004-07-01), El Haj
patent: WO 95/06248 (1995-03-01), None
patent: WO 01/88540 (2001-11-01), None
patent: WO 02/051985 (2002-07-01), None
O'Grady et al., Molecular diversity and function of voltage-gated (Kv) potassium channels in epithelial cells, 2005, The International Journal of Biochemistry and Cell Biology, vol. 37, pp. 1578-1594.
Yanase et al., Intracellular hyperthermia for cancer using magnetite cationic liposomes: Ex vivo study, 1997, Japanese Journal of Cancer Research, vol. 88, pp. 630-632.
Yanase et al., Intracellular hyperthermia for cancer using magnetite cationic liposomes: an in vivo study, 1998, Japanese Journal of Cancer Research, vol. 89, pp. 463-469.
Ito et al., Medical Application of functionalized magnetic nanoparticles, 2005, Journal of Bioscience and Bioengineering, vol. 100, pp. 1-11.
Komarova et al., Osteoclast ion channels: potential targets for antiresportive drugs, 2001, Current Pharmaceutical Design, vol. 7, pp. 637-654.
Ullrich et al., Expression of voltage-activated chloride currents in acute slices of human gliomas, 1998, Neuroscience, vol. 83, Issue 4, pp. 1161-1173.
Cartmell et al., “Development of Magnetic Particle Techniques for Long-Term Culture of Bone Cells With Intermittent Mechanical Activation,”IEEE Trans. Nanobiosci. 1:92-97 (2002).
Cartmell et al., “Preliminary Analysis of Magnetic Particle Techniques for Activating Mechanotransduction in Bone Cells,”IEEE, pp. 87-88 (2002).
Glogauer et al., “Magnetic Fields Applied to Collagen-Coated Ferric Oxide Beads Induce Stretch-Activated Ca2+Flux in Fibroblasts,”Am. J. Physiol. 269:C1093-C1104 (1995).
Dobson and St. Pierre, “Application of the Ferromagnetic Transduction Model to D.C. and Pulsed Magnetic Fields: Effects on Epileptogenic Tissue and Implications for Cellular Phone Safety,”Biochem. Biophys. Res. Comm. 227:718-723 (1996).
Dobson and El Haj, “Theoretical Evaluation of the Magnetic Force Bioreactor,” Internet Article, ′Online! XP002257583, Retrieved from the Internet: <URL:http://www.maths.nottingham.ac.uk/Cmm/MMSG2001/SGprobsInf.html>, retrieved on Jul. 31, 2001, Abstract.
Mykhaylyk et al., “Signal Transduction of Erythrocytes After Specific Binding of Ecdysterone and Cholesterol Immobilized on Nanodispersed Magnetite,”J. Magn. Magn. Mater. 225:226-234 (2001).
Schütt et al., “Applications of Magnetic Targeting in Diagnosis and Therapy—Possibilities and Limitations: A Mini-Review,”Hybridoma 16:109-117 (1997).
Yang, Ying et al., “Development of a ‘mechano-active’ scaffold for tissue engineering.” Biomaterials, vol. 23 pp. 2119-2126 (2002).
Santra, Swadeshmukul, “Synthesis and Characterization of Silica-Coated Iron Oxide Nanoparticles in Microemulsion: The Effect of Nonionic Surfactants,” vol. 17 pp. 2900-2906 (2001).
Hughes, Steven, et al. “Magnetic targeting of mechanosensors in bone cells for tissue engineering applications.” Journal of Biomechanics, vol. 40 (2007) pp. S96-S104.
Cartmell, Sarah H., et al. '“Development of Magnetic Particle Techniques for Long-Term Culture of Bone Cells with Intermittent Mechanical Activation.” IEEE Transactions on Nanobioscience, vol. 1 No. 2 (2002) pp. 92-97.
Dobson, Jon, et al. “Principles and Design of a Novel Magnetic Force Mechanical Conditioning Bioreactor for Tissue Engineering, Stem Cell Conditioning, and Dynamic in Vitro Screening.” IEEE Transactions on Nanobioscience, vol. 5 No. 3 (2006) pp. 173-177.
Hughes, Steven, et al. “Expression of the Mechanosensitive 2PK+ Channel TREK-1 in Human Osteoblasts.” Journal of Cellular Physiology, vol. 206 pp. 738-748 (2006).
Hughes, Steven, et al. “Selective activation of mechanosensitive ion channels using magnetic particles.” J.R. Society Interface, vol. 5 pp. 855-863 (2008).
Wolbank, S., et al. “In vivo tracking of stem cells using magnetic tagging in a nude mouse model” Journal of Biomechanics, vol. 39 pp. S447 (2006).
El Haj, A.J., et al. “Magnetic nanoparticle-based tagging of mechanosensors for bone tissue engineering.” Journal of Biomechanics, vol. 39 pp. S214 (2006).
Wang, J., et al., “Force regulates smooth muscle actin in cardiac fibroblasts,” Am J. Physiol Heart Circ Physiol, vol. 279, pp. H2776-2785 (2000).
Maingret, Francois, et al., “Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel,” The Journal of Biological Chemistry, vol. 274, No. 38, pp. 26691-26696 (Sep. 17, 1999).
Laniado, Marc E., et al., “Voltage-Gated K+ Channel Activity in Human Prostate Cancer Cell Lines of Markedly Different Metastatic Potential: Distinguishing Characteristics of PC-3 and LNCaP Cells,” The Prostate, vol. 46, pp. 262-274 (2001).
Mitsugu, Yanase, et al., “Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: An in vivo Study.” Jpn. J. Cancer Res. vol. 89, pp. 463-469 (Apr. 1998).

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