Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-01-26
1997-12-30
Crouch, Deborah
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4241301, 4241841, 435 693, 935 60, 935 65, A61K 4800, A61K 39395, A61K 3900, C12P 2106
Patent
active
057030553
ABSTRACT:
A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy. In particular, a method is disclosed for the generation of detectable antibodies by the direct administration to a tissue in a mammal a DNA sequence encoding a immunogen where the DNA is complexed to a cationic lipid.
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Carson Dennis A.
Felgner Philip L.
Malone Robert Wallace
Rhodes Gary H.
Wolff Jon Asher
Crouch Deborah
Vical Incorporated
Wisconsin Alumni Research Foundation
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