Generation of acyl amino acids

Details Generation of acyl amino acids Generation of acyl amino acids

2011-07-19

2011-07-19

Joike, Michele (Department: 1636)

Chemistry: analytical and immunological testing

Nitrogen containing

Amine and quaternary ammonium

C435S106000

Reexamination Certificate

active

07981685

ABSTRACT:
Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.

REFERENCES:
patent: 5652116 (1997-07-01), Grandi et al.
patent: 5795738 (1998-08-01), Grandi et al.
patent: 6060051 (2000-05-01), Heins et al.
patent: 6103228 (2000-08-01), Heins et al.
patent: 6291426 (2001-09-01), Heins et al.
patent: 6417163 (2002-07-01), Heins et al.
patent: 6638910 (2003-10-01), Heins et al.
patent: 2010/0297751 (2010-11-01), Marahiel et al.
Steller et al. Initiation of Surfactin Biosynthesis and the Role of the SrfD-Thioesterase Protein. Biochem. 43: 11331-11343, 2004.
Assie et al., “Insecticide activity of surfactins and iturins from a biopesticideBacillus subtilisCohn (S499 strain)”Meded Rijksuvin Gent Fak Landbouwkd Toegep Biol Wet., 67(3):647-655 (2002) Abstract only.
ATCC8185 http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=8185&Template=bacteria.
Bruner et al., “Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE”Structure, 10:301-310 (2002).
Coque et al., “The Cephamycin Biosynthetic GenespcbAB, Encoding a Large Multidomain Peptide Synthetase, andpcbCofNocardia lactamduransare Clustered Together in an Organization Different from the Same Genes inAcremonium chrysogenumandPenicillium chrysogenum,” Mol. Microbiol.5:1125, 1991.
Cosmina et al., “Sequence and Analysis of the Genetic Locus Responsible for Surfactin Synthesis inBacillus subtilis,” Mol. Microbiol.8 (5) 821, 1993.
de Ferra et al., “Engineering of Peptide Synthetases,”Journal of Biological Chemistry272:40, 25304-25309, 1997.
Diez et al., “The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes,”J. Biol. Chem.265(27):16358-16365, 1990.
Fields et al., “A Novel Genetic System to Detect Protein-Protein Interactions,”Nature340 :245-6, 1989.
International Preliminary Report on Patentability from PCT/US08/060474, dated Oct. 20, 2009.
International Search Report from PCT/US08/60474, dated Oct. 21, 2008.
Kleinkauf et al., “Biosynthesis of Peptide Antibiotics,”Annu. Rev. Microbiol., 41:259-289, 1987.
Krätzxchmar et al., “Gramicidin S Biosynthesis Operon Containing the Structural GenesgrsAandgrsBHas an Open Reading Frame Encoding a Protein Homologous to Fatty Acid Thioesterases,”J. Bacteriol.171 (10) 5422-5429, 1989.
Lait et al., “Rapid biosynthesis of N-linolenoyl-L-glutamine, an elicitor of plant volatiles, by membrane-associated enzyme(s) inManduca sexta” PNAS USA, 100(12):7027-7032 (2003).
MacCabe et al., “δ-(L-α-Aminoadipyl)-L-Cysteinyl-D-Valine Synthetase fromAspergillus nidulans,” J. Biol. Chem.266:12646, 1991.
Nagai et al., “Study on Surfactin, A Cyclic Depsipeptide. II. Synthesis of Surfactin B2Produced byBacillus nattoKMD 2311,”Chem Pharm Bull(Tokyo) 44 (1) 5-10, 1996.
Richardt et al., “Ebony, a Novel Nonribosomal Peptide Synthetase for Beta-Alanine Conjugation with Biogenic Amines inDrosophila,” J. Biol. Chem., 278(42):41160-41166, 2003.
Smith et al., “The Multifunctional Peptide Synthetase Performing the First Step of Penicillin Biosynthesis inPenicillium chrysogenumis a 421 073 Dalton Protein Similar toBacillus brevisPeptide Antibiotic Synthetases,”EMBO J.9 (9) 2743-2750, 1990.
Smith et al., “β-Lactam Antibiotic Biosynthetic Genes Have Been Conserved in Clusters in Prokaryotes and Eukaryotes,”EMBO J.9 (3) 741-747, 1990.
Written Opinion of the ISA from PCT/US08/60474, dated Oct. 21, 2008.

Affiliated with

Also associated with

Rating

Generation of acyl amino acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Generation of acyl amino acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Generation of acyl amino acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2666205