Generation and screening of synthetic drug libraries

Details Generation and screening of synthetic drug libraries Generation and screening of synthetic drug libraries

1994-02-09

1997-01-14

Kight, John

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 4, 435 32, 536 111, 536118, 5361231, 536115, C12Q 102, C12Q 100, C12Q 118

Patent

active

055938531

ABSTRACT:
Methods are provided for generating highly diverse mixtures of compounds which may be screened for biological activities. Once the activity is found, the component of the mixture which is responsible for the activity can be isolated by fractionation and assay for the biological activity. Polyhydroxylated organic monomers and oligomers are used as starting materials for generating the libraries.

REFERENCES:
patent: 3251827 (1966-05-01), Schnell et al.
patent: 3859318 (1975-01-01), Lesuer
patent: 4005195 (1977-01-01), Jandacek
patent: 4241054 (1980-12-01), Volpenhein et al.
patent: 4260827 (1981-04-01), Klinkmann et al.
patent: 4631211 (1986-12-01), Houghten
patent: 4833092 (1989-05-01), Geysen
patent: 5223409 (1993-06-01), Ladner et al.
Nielsen, et al., "Synthetic Methods for the Implementation of Encoded Combinatorial Chemistry", J. Am. Chem. Soc., 115:9812-9813 (1993).
Lowman, et al., "Selecting High-Affinity Binding Proteins by Monvalent Phage Display", Biochemistry, 30:10832-10838 (1991).
Amato, "Speeding Up a Chemical Game of Chance", Science, 257:330-331 (1992).
Brenner, et al., "Encoded Combinatorial Chemistry", Proc. Natl. Acad. Sci. USA, 89:5381-5383 (1992).
Ganellin, "Past Aproaches to Discovering New Drugs", Medicinal Chemistry for the 21st Century, Ed. by Wermuth, Koga, Konig, and Metcalf, Blackwell Scientific Publications, London, pp. 3-12, 1992.
Jung, et al., "Multiple Peptide Synthesis Methods and Their Applications", Angewandt Chemie, 31(4):367-383 (1992).
Bradley, "How to Create a Drug Library", New Scientists, Issue of Feb. 13, 1993.
Barry, et al., "Susceptibility Tests: Diffusion Test Procedures", 4th Edition of Manual of Clinical Microbiology, ed. by Lennette, American Society for Microbiology, Washington, D.C., pp. 978-987, 1985.
Glasr, "Peptide Synthesis and Screening Strategies for Drug Development", Genetic Engineering News, Issue of May 1, 1993.
Potera, "In Vitro Evolution Creates Novel Drugs", Genetic Engineering News, Issue of Apr. 15, 1993.
"IXSYS Licenses In Vitro Monoclonal Process", Genetic Technology News, 12(10):14, Oct. 1992.
"Progenics Improves the Screening Process", Genetic Gechnology News, 9(5):5, May 1989.
Baum, "Combinatorial Approaches Provide Fresh Leads for Medicinal Chemistry", C&EN, Feb. 7, 1994.
Stone, "The Hot New Field of Molecular Diversity", Bio/Technology, 11:1508-1509, Dec. 1993.

Affiliated with

Also associated with

Rating

Generation and screening of synthetic drug libraries does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Generation and screening of synthetic drug libraries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Generation and screening of synthetic drug libraries will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1387398