Boots – shoes – and leggings
Patent
1993-10-25
1996-02-27
Trammell, James P.
Boots, shoes, and leggings
364578, G06F 1750
Patent
active
054954231
ABSTRACT:
A method for computing the conformation and location that a protein fragment will obtain in binding to the active site of a receptor is provided. The invention relates to both the computation of conformation and location of natural ligands within an active site and the design of artificial ligands with useful binding characteristics.
REFERENCES:
patent: 4704692 (1987-11-01), Ladner
patent: 4881175 (1989-11-01), Ladner
patent: 4908773 (1990-03-01), Pantoliano et al
patent: 4939666 (1990-07-01), Hardman
patent: 5025388 (1991-06-01), Cramer, III et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5241470 (1993-08-01), Lee et al.
patent: 5307287 (1994-04-01), Cramer, III et al.
patent: 5331573 (1994-07-01), Balaji et al.
patent: 5434796 (1995-07-01), Weininger
M. A. Saper, et al. "Refined Structure of the Human Histocompatibility Antigen HLA-A2 at 2.6 .ANG.Resolution" Journal of Molecular Biology 219:277-319 (1991).
France Latron, et al. "Positioning of a peptide in the cleft of HLA-A2 by complementing amino acid changes" Proc. Natl. Acad. Sci. USA 88:11325-11329 (1991).
David Eisenberg, et al. "Solvation energy in protein folding and binding" Nature 319:199-203 (1986).
Joseph A. Ippolito, et al. "Hydrogen Bond Stereochemistry in Protein Structure and Function" Journal of Molecular Biology 215:457-471 (1990).
Timothy J. Richmond, "Solvent Accessible Surface Area and Excluded Volume in Proteins" Journal of Molecular Biology 178:63-89 (1984).
T. P. J. Garrett, et al. "Specificity pockets for the side chains of peptide antigens in HLA-Aw68" Nature 342:692-696 (1989).
P. J. Bjorkman, et al. "Structure of the human class I histocompatibility antigen, HLA-A2" Nature 329:506-518 (1987).
Ronald N. Germain "The second class story" Nature 353:605-607 (1991).
Olaf Rotzschke, et al. "Naturally-occurring peptide antigens derived from the MHC class-I-restricted processing pathway" Immunology Today 12:447-455 (1991).
Bernard R. Brooks, et al. "CHARMM: A Program for Macromolecular Energy, Minimization, and Dynamics Calculations" Journal of Computational Chemistry 4:187-217 (1983).
Charles DeLisi, et al. "T-cell antigenic sites tend to be amphipathic structures" Proc. Natl. Acad. Sci. USA 82:7048-7052 (1985).
R. Rosenfeld, et al., "Computing the Structure of Bound Peptides" J. Mol. Biol. 234:515-521 (1993).
U. Sezerman, et al., "Toward computational determination of peptide-receptor structure" Protein Science 2:1827-1843 (1993).
Cornette James L.
DeLisi Charles
Rosenfeld Rakefet
Sezerman Ugur
Vajda Sandor
Choi Kyle J.
Trammell James P.
Trustees of Boston University
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