Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1988-05-02
1991-04-23
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530333, C07K 100, C07K 104
Patent
active
050101757
ABSTRACT:
A method to obtain selected individual peptides or families thereof which have a target property and optionally to determine the amino acid sequence of a selected peptide or peptides to permit synthesis in practical quantities is disclosed. In general outline, the method of the invention comprises synthesizing a mixture of randomly or deliberately generated peptides using standard synthesis techniques, but adjusting the individual concentrations of the components of a mixture of sequentially added amino acids according to the coupling constants for each amino acid/amino acid coupling. The subgroup of peptides having the target property can then be selected, and either each peptide isolated and sequenced, or analysis performed on the mixture to permit its composition to be reproduced. Also included in the invention is an efficient method to determine the relevant coupling constants.
REFERENCES:
Creighton, T. E., Proteins, Wett. Freeman & Co., 1984, pp. 39-45.
Lu, Hsieng et al., Chem. Abs., 106(1):2453f, 1986.
Rutter William J.
Santi Daniel V.
Perkins Susan M.
Schain Howard E.
The Regents of the University of California
LandOfFree
General method for producing and selecting peptides with specifi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with General method for producing and selecting peptides with specifi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and General method for producing and selecting peptides with specifi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1622404