Gene transfer using transformed, neodetermined, embryonic cells

Details Gene transfer using transformed, neodetermined, embryonic cells Gene transfer using transformed, neodetermined, embryonic cells

1987-01-16

1991-07-16

Weimar, Elizabeth C.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

424 93, 424582, 4351723, 4352402, 800 2, 935 62, A61K 3500, C12N 1500, C12N 500

Patent

active

050324071

ABSTRACT:
This invention is directed to a method for the preparation of carrier cells capable of delivering exogenous genetic material to a particular tissue of the body by means of embryonic cells competent to develop into that tissue, and essentially only that tissue, said cells bearing the exogenous genetic material. The preferred carrier cells are mesodermal cells of the yolk sac or embryonic forebrain or midbrain cells, and the desired genetic material is preferably introduced into the cells by in vitro transformation with an amphotrophic retroviral vector.

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