Gene transfer into bone cells and tissues

Details Gene transfer into bone cells and tissues Gene transfer into bone cells and tissues

1994-02-18

1998-06-09

Ziska, Suzanne E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4351723, 4353201, 536 231, 536 235, 536 2351, 514801, 424600, 424423, 424422, 424484, 424486, C12N 1500, C07H 2102, C07H 2104, A61K 4800

Patent

active

057634165

ABSTRACT:
Disclosed are methods, compositions and devices for use in transferring nucleic acids into bone cells in situ. The transfer of an osteotropic gene into bone progenitor cells is described, which event is shown to stimulate the progenitor cells and to promote bone growth, repair and regeneration in vivo. These gene transfer protocols are suitable for use in transferring various nucleic acid materials into bone, and have many uses, for example, in treating various bone-related diseases and defects, such as, in promoting fracture repair, use in connection with implants, and in treating osteoporosis and osteogenesis imperfecta.

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