Gene transfer in intact mammals

Details Gene transfer in intact mammals Gene transfer in intact mammals

1982-12-08

1985-02-05

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 94, 435 68, 4351723, 435241, 935 62, 935 71, 935 70, A61K 3512

Patent

active

044977964

ABSTRACT:
Methods and compositions are provided for gene transfer to intact mammals with expression of the exogenous genetic material in the host. Mammalian host cells which are regenerative, normally highly proliferative or subject to induced proliferation, are transformed or modified in vitro with DNA capable of replication and expression in the host cell, wherein the DNA becomes incorporated into the cell. The modified cells are found to regenerate in the host with expression of the introduced DNA. Particularly, mammalian cells were modified with genes providing for overproduction of a particular enzyme. The modified cells were reintroduced in the host under conditions providing for selective advantage of the modified cells.

REFERENCES:
patent: 4172124 (1979-10-01), Koprowski et al.
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4276282 (1981-06-01), Sugimoto et al.
patent: 4285929 (1981-08-01), Sugimoto et al.

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