Gene transfer in intact mammals

Details Gene transfer in intact mammals Gene transfer in intact mammals

1980-03-26

1983-08-02

Rosen, Sam

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 95, 424101, 424251, 435172, 435241, A61K 3748, A61K 3514

Patent

active

043966012

ABSTRACT:
Methods and compositions are provided for gene transfer to intact mammals with expression of the exogenous genetic material in the host. Mammalian host cells which are regenerative, normally highly proliferative or subject to induced proliferation, are transformed or modified in vitro with DNA capable of replication and expression in the host cell, wherein the DNA becomes incorporated into the cell. The modified cells are found to regenerate in the host with expression of the introduced DNA. Particularly, mammalian cells were modified with genes providing for overproduction of a particular enzyme. The modified cells were reintroduced in the host under conditions providing for selective advantage of the modified cells.

REFERENCES:
patent: 4172124 (1979-10-01), Koprowski et al.
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4276282 (1981-06-01), Sugimoto et al.
patent: 4285929 (1981-08-01), Sugimoto et al.
Cline et al.-Nature, vol. 284, Apr. 3, 1980, pp. 422-425.
Hilts-The Washington Post, Oct. 16, 1980, p. A7.
Orlova et al.-Chem. Abst., vol. 92 (1980), p. 20,448e.
McElwain et al.-Chem. Abst., vol. 92 (1980), p. 15767d.

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