Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-07
1998-06-23
Campbell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4351723, 536 241, 935 36, A61K 4800
Patent
active
057705810
ABSTRACT:
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding sequences encoding DNA binding, activation or repression domains of a transcription factor. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.
REFERENCES:
patent: 4667063 (1987-05-01), Mark et al.
patent: 5571797 (1996-11-01), Ohno et al.
Abou-Shoer et al., Flavonoids From Koelreuteria Henryi And Other Sources As Protein-Tyrosine Kinase Inhibitors, J. Nat. Proc., 56(6):967-9, 1993.
Alexandropoulos et al., "v-Fps-Responsiveness in the Egr-1 Promoter is Mediated by Serum Response Elements," Nucleic Acids Research, 20(9):2355-2359, 1992.
Al-Khodiary and Carr, DNA repair mutants defining G.sub.2 checkpoint pathways in Schizosaccharomyces pombe, The EMBO Journal, 11(4):1343-1350, 1992.
Angel et al., "The jun Proto-Oncogene is Positively Autoregulated by its Product, Jun/AP-1," Cell, 55:875-885, 1988.
Atherton-Fessler et al., "Mechanisms of p34.sup.cdc2 Regulation," Molecular and Cellular Biology, 13(3):1675-1685, 1993.
Attar et al., "Expression Cloning of a Novel Zinc Finger Protein that Binds to the c-fos Serum Response Element," Molecular and Cellular Biology, 12(5):2432-2443, 1992.
Barbet and Carr, "Fission yeast weel protein kinase is not required for DNA damage-dependent mitotic arrest," Nature, 364:824-827, 1993.
Baumann et al., "Response of Xenografts of Human Malignant Gliomas and Squamous Cell Carcinomas to Fractionated Irradiation," J. Radiation Oncology Biol. Phys., 23(4):803-809, 1992.
Beutler and Cerami, "Tumor Necrosis, Cachexia, Shock, and Inflammation: A Common Mediator," Ann. Rev. Biochem., 57:505-518, 1988.
Bhuyan et al., "Lethality, DNA Alkylation, and Cell Cycle Effects of Adozelesin (U-73975) on Rodent and Human Cells," Cancer Research, 52:5687-5692, 1992.
Boothman et al., "Identification and Characterization of X-Ray-Induced Proteins in Human Cells," Cancer Research, 49:2871-2878, 1989.
Brach et al., "Ionizing Radiation Induces Expression and Binding Activity of the Nuclear Factor .sub. KB," J. Clin. Invest., 88:691-695, 1991.
Buchdunger et al., "4,5-Dianilinophthalimide: A protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity," Proc. natl. Acad. Sci. USA, 91:2334-2338, 1994.
Budach et al., "The TCD.sub.50 and Regrowth Delay Assay in Human Tumor Xenografts: Differences and Implications," Int. J. Radiation Oncology Biol. Phys., 25, 259-268, 1993.
Cantley et al., Oncogenes and Signal Transduction, Cell, 64:281-302, 1991.
Chan et al., "Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor," Biochemical and Biophysical Research Communications, 193(3):1152-1158, 1993.
Chen et al., "Structure of malhamensilipin A, an inhibitor of protein tyrosine kinase, from the cultured chrysophyte poterioochromonas malhamensis," Journal of Natural Products, 57(4):524-527, 1994.
Datta et al., "Involvement of Reactive Oxygen Intermediates in the Induction of c-jun Gene Transcription by Ionizing Radiation," Biochemistry, 31(35):8300-8306, 1992.
Datta et al., "Ionizing Radiation Activates Transcription of the EGR1 Gene Via CarG Elements," Proc. Natl. Acad. Sci. USA, 89(21):10149-10153, Nov., 1992.
Datta et al., "Reactive Oxygen Intermediates Target CC(A/T).sub.6 GG Sequences to Mediate Activation of the Early Growth Response 1 Transcription Factor Gene by Ionizing Radiation," Proc. Natl. Acad. Sci. USA, 90:2419-2422, 1993.
Devary et al., "The Mammalian Ultraviolet Response is Triggered by Activation of Src Tyrosine Kinases," Cell, 71:1081-1091, 1992.
Enoch and Nurse, "Mutation of Fission Yeast Cell Cycle Control Genes Abolishes Dependence of Mitosis on DNA Replication," Cell, 60:665-673, 1990.
Gillespie et al., "Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors," Br. J. Cancer, 68:1122-1126, 1993.
Gould et al., "Complementation of the Mitotic Activator, p80.sup.cdc25, by a Human Protein-Tyrosine Phosphatase," Science, 250:1573-1576, 1990.
Gubits et al., "Expression of Immediate Early Genes after Treatment of Human Astrocytoma Cells with Radiation and Taxol," Int. J. Radiation Oncology Biol. Phys., 27(3):637-642, Oct., 1993.
Gustafson et al., "Hydrogen Peroxide Stimulates Phospholipase A.sub.2 -Mediated Archidonic Acid Release in Cultured Intestinal Epithelial Cells (INT 407)," Archidonic Acid Release, 26:237-247, 1991.
Hallahan et al., "Increased tumor necrosis factor .alpha. mRNA after cellular exposure to ionizing radiation," Proc. Natl. Acad. Sci. USA, 86:10104-10107, 1989.
Hallahan et al., "Inhibition of Protein Kinases Sensitizes Human Tumor Cells to Ionizing Radiation," Radiation Research, 129:345-350, 1992.
Hallahan et al., "Ketoconazole Attenuates Radiation-Induction of Tumor Necrosis Factor," Int. J. Radiation Oncology, in press, 1994.
Hallahan et al., "Mechanisms of X-Ray Mediated Protooncogene c-jun Expression in Radiation-Induced Human Sarcoma Cell Lines," Int. J. Radiation Oncology Biol. Phys., 21(6):1677-1681, 1991.
Hallahan et al., "Membrane-Derived Second Messenger Regulates X-Ray-Mediated Tumor Necrosis Factor a Gene Induction," Proc. Natl. Acad. Sci. USA, 91:4897-4901, May 1994.
Hallahan et al., "Phase I Dose Escalation Study of Tumor Necrosis Factor and Radiation," International Journal of Radiation Oncology Biology, Physics, 27(1):184 Abstract 94, 1993.
Hallahan et al., "Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN," Proc. Natl. Acad. Sci. USA, 88:2156-2160, 1991.
Hallahan et al., "Radiation Signaling Mediated by Jun Activation Following Dissociation from a Cell Type-Specific Repressor," J. Biol. Chem., 268(7):4903-4907, Mar. 1993.
Hallahan et al., "The Role of Cytokines in Radiation Oncology," Important Advances in Oncology, 1993.
Hallahan et al., "Transcriptional regulation of the TNF gene by x-irradiation," Proc. Am. Assoc. Cancer Res., 31(0):75, 1990.
Hallahan et al., "Tumor Necrosis Factor Gene Expression Is Mediated by Protein Kinase C following Activation by Ionizing Radiation," Cancer Research, 51:4565-4569, 1991.
Hartley, et al., "DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells," Nucleic Acids Research, 20(12):3175-3178, 1992.
Hartwell and Weinert, "Checkpoints: Controls that Ensure the Order of Cell Cycle Events," Science, 246:629-634, 1989.
Hempel et al., "Tyrosine Phosphorylation of Phospholipase C-1.sub.2 upon Cross-linking of Membrane Ig on Murine B Lymphocytes," The Journal of Immunology, 148(10):3021-3027, 1992.
Herrlich et al., "DNA Damage-Induced Gene Expression: Signal transduction and Relation to Growth Factor Signaling," Rev. Physiol. Biochem. Pharmacol., 119:187-223, 1992.
Hollander and Fornace, "Induction of fos RNA by DNA-damaging Agents," Cancer Research, 49:1687-1692, 1989.
Hsu et al., "Inhibition Kinetics and Selectivity of the Tyrosine Kinase Inhibitor Erbstatin and a Pyridone-Based Analogue," Biochemical Pharmacology, 43(11):2471-2477, 1992.
Hwu et al., "Functional and Molecular Characterization of Tumor-Infiltrating Lymphocytes Transduced with Tumor Necrosis Factor-a cDNA for the Gene Therapy of Cancer in Humans," The Journal of Immunology, 150(9):4104-4115, May 1993.
Jayasuriya et al., "Emodin, A Protein Tyrosine Kinase Inhibitor From Polygonum Cuspidatum," J. Nat. Proc., 55(5):696-8, 1992.
Kastan et al., "Participation of p53 Protein in the Cellular Response to DNA Damage," Cancer Research, 51:6304-6311, 1991.
Lambert and Borek, "X-ray-Induced Changes in Gene Expression in Normal and Oncogene-Transformed Rat Cell Lines," Journal of the National Cancer Institute, 80(18):1492-1497, 1988.
Luna et al., "Photodynamic Therapy Mediated Induction of Early Response Gene
Hallahan Dennis E.
Kufe Donald W.
Sukhatme Vikas P.
Weichselbaum Ralph R.
Arch Development Corp.
Campbell Bruce R.
Dana-Farber Cancer Institute
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