Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-05-09
2006-05-09
Chen, Shin-Lin (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023100, C536S023500, C536S024100, C424S093100, C424S093200, C435S455000
Reexamination Certificate
active
07041653
ABSTRACT:
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding sequences encoding DNA binding, activation or repression domains of a transcription factor. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.
REFERENCES:
patent: 4370417 (1983-01-01), Hung et al.
patent: 4667063 (1987-05-01), Ball
patent: 4677064 (1987-06-01), Mark et al.
patent: 4833080 (1989-05-01), Brent et al.
patent: 4835098 (1989-05-01), Orr et al.
patent: 5206152 (1993-04-01), Sukhatme
patent: 5571797 (1996-11-01), Ohno et al.
patent: 5612318 (1997-03-01), Weichselbaum et al.
patent: 5770581 (1998-06-01), Weichselbaum et al.
patent: 5817636 (1998-10-01), Weicheselbaum et al..
patent: 6156736 (2000-12-01), Weicheselbaum et al.
patent: 6605712 (2003-08-01), Weicheselbaum et al.
patent: 0273085 (1988-07-01), None
patent: WO 92/11033 (1991-12-01), None
patent: WO 94/09699 (1994-05-01), None
patent: WO 95/06128 (1995-03-01), None
patent: WO 95/27071 (1995-10-01), None
patent: WO 99/32619 (1999-07-01), None
patent: WO 01/36646 (2001-05-01), None
patent: WO 01/68836 (2001-09-01), None
Verma et al., Sep. 1997, Nature, vol. 389, pp. 239-242.
Eck et al., 1996, Goodman & Gilman's The Pharmacological Basis of Therapeutics, McGraw-Hill, New York, p. 77-101.
Gorecki, 2001, Expert Opin. Emerging Drugs, 6(2): 187-198.
U.S. Appl. No. 07/633,626 filed Dec. 20, 1990, Weicheselbaum et al.
U.S. Appl. No. 08/035,897 filed Mar. 18, 1993, Weicheselbaum et al.
Abate et al., “Redox regulation of Fos and Jun DNA-binding activity in vitro,” Science (1990) 249:1157-1161.
Abou-Shoer et al., “Flavonoids from Koelreuteria Henryi and other sources as protein-tyrosine kinase inhibitors,” J. Nat. Proc. (1993) 56(6):967-969.
Advani, S. et al., “Enhancement of replication of genetically engineered herpes simplex virus by ionizing radiation: a new paradigm for destruction of intractable tumors,”Gene Therapy(1998) 5:160-165.
Ainsworth, E.J. and Chase, H.B., “Effect of microbial antigens on irradiation mortality in ice,”Proc. Soc. Exp. Biol. Med.(1959) 102:483.
Al-Khodiary and Carr, “DNA repair mutants defining G2 checkpoint pathways in schizosaccaromyces pombe,” The EMBO Journal (1992) 11(4):1343-1350.
Alberts et al., Molecular Biology of the Cell (3rd Ed.) 425.
Alexander et al.,J. Clin. Oncol.(1998) 16:1479-1489.
Alexandropoulos, K. et al., “v-Fps-responsiveness in the Egr-1 Promoter is Mediated by Serum Response Elements,” Nucleic Acids Research (1992) 20(9):2355-2359.
Andrews, G.K. et al., “The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene,” Mol. Cell Biol. (1987) 7:3452-3458.
Angel et al., “The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1,” Cell (1988) 55:875-885.
Angel, P. et al., “12-O-Tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in 5'-flanking region,” Mol. Cell Biol. (1987) 7:2256-2266.
Angel, P. et al., “Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts,” Mol. Cell Biol. (1986) 6:1760-1766.
Angel, P. et al., “Oncogene jun encodes a sequence-specific trans-activator similar to AP-1,” Nature (1988) 332:166-171.
Arai et al., “Cytokines: Coordinators of immune and inflammatory responses,”Ann Rev. Biochem.(1990) 59:783-785.
Arap et al.,Cancer Res.(1995) 55:1351-1354.
Atherton-Fessler et al., “Mechanisms of p34cdc2 regulation,” Molecular and Cellular Biology (1993) 13(3):1675-1685.
Attar et al., “Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element,” Molecular and Cellular Biol. (1992) 12(5):2432-2443.
Baichwal, V.R. and Tjian, R., “Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: differences between v-and c-Jun,” Cell(1990) 63:815-825.
Baichwal, V.R. et al., “v-SRC and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitor”, Nature (1991) 352:165-168.
Ballard, D.W. et al., “The 65-kDa subunit of human NF-kB functions as a potent transcriptional activator and a target for v-REL-mediated repression,”Proc. Natl. Acad. Sci USA(1992) 89:1875-1879.
Barbet and Carr, “Fission yeast wee1 protein kinase is not required for DNA damage-dependent mitotic arrest,” Nature (1993) 364:824-827.
Baumann et al., “Response of xenografts of human malignant gliomas and squamous cell carcinomas to fractionated irradiation,” J. Radiation Oncology Biol. Phys. (1992) 23(4):803-809.
Becker, R.C. et al., “Recombinant tissue-type plasminogen activator: Current concepts and guidelines for clinical use in acute myocardial infarction. Part I.,”Am Heart J.(1991) 220-244.
Bedzyk, et al., “Immunological and structural characterizatioN of a high affinity anti-fluorescein single-chain antibody,”J. Biol. Chem.(1990) 265: 18615-18620.
Benvenisty and Reshif, “Direct introduction of genes into rats and expression of the genes,”Proc. Natl. Acad. Sci. USA(1986) 83(24):9551-9555.
Bernstein et al.,Cell Growth and Diff.(1991) 2:273-278.
Bernstein, L.R. and Colburn, N.H., “AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells,” Science (1989) 244:566-569.
Beutler and Cerami, “Tumor necrosis, cachexia, shock and inflammation: a common mediator,” Ann, Rev. Biochem. (1988) 57:505-518.
Bevilacqua et al.,Science(1989) 243:1160-1165.
Bhuyan et al., “Lethality, DNA alkylation, and cell cycle effects of adozelesin (U-73975) on rodent and human cells,”Cancer Research(1992) 52:5687-5692.
Binetruy, B. et al., “Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain,”Nature(1991) 351:122-127.
Blaese, M. et al., “Vectors in cancer therapy: how will they deliver?” Cancer Gene Therapy (1995) 2(4):291-297.
Blaese et al., “T-Lymphocyte-directed gene therapy, for ADA-SCID: Initial trial results after 4 years,” Science (1995) 270:475-480.
Blomer et al., “Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector,”J. Virol.(1997) 71(9):6641-6649.
Bohmann et al.,Science(1987)238:1386-1392.
Bonthron et al., “Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing,”Proc. Natl. Acad. Sci.USA (1988) 85:1492-1496.
Bonura, T. and Smith, K.C., “The involvement of indirect effects in cell-killing and DNA double-strand breakage in β-irradiated Escherichia coli K-12, ”Int. J. Radiat. Biol.(1976) 293-296.
Boothman, D.A. et al., “Identification and characterization of x-ray-induced proteins in human cells,”Cancer Research(1989) 49:2871-2878.
Borek, “The induction and control of radiogenic transformation in vitro: cellular and molecular mechanisms,” Pharmacol. Ther. (1985) 27:99-142.
Bosher and Labouesse,Nat. Cell Biol.(2000) 2:E31-E36.
Brach, M.A. et al., “Ionizing radiation induces expression and binding activity of the nuclear factor kB,”The American Soc. for Clinical Invest. Inc.(1991) 88:691-695.
Braddock, “The transcription factor Egrl: a potential drug in wound healing and tissue repair,”Ann. Med.(2001) 33:313-318.
Breakefield et al., “Herpes simplex virus for gene delivery to neurons,”New Biologist(1991) 3:203-218.
Brenner et al.,Nature(1989) 337(6208):661-663.
Brott, T.,Cerebrovase Brain Metab.(1991) 3:91-113.
Brown et al.,J. Immunother.(
Hallahan Dennis E.
Kufe Donald W.
Sukhatme Vikas P.
Weichselbaum Ralph R.
Chen Shin-Lin
Dana-Farber Cancer Institute Inc.
Michael & Best & Friedrich LLP
The University of Chicago
LandOfFree
Gene transcription and ionizing radiation: methods and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene transcription and ionizing radiation: methods and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene transcription and ionizing radiation: methods and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3532707